Sanal O, Ustaçelebi S, Başaran M, Aysun S, Ersoy F, Berkel A I
Boll Ist Sieroter Milan. 1985;64(5):400-3.
Spontaneous cytotoxicity towards LU106 (heteroploid human lung cell line) cells persistently and acutely infected with measles virus was studied in measles immune and nonimmune healthy subjects and SSPE patients. K562 (myeloid cell line) cells were also used to detect the NK activity. Specific cytotoxic responses for measles immune and nonimmune donors were not significantly different for both persistently and acutely measles infected LU106 cells indicating that our assay system detected NK activity. Cytotoxic responses of SSPE patients against virus infected and K562 cells were found to be within normal limits in 3 and 5 patients respectively.
在麻疹免疫和非免疫的健康受试者以及亚急性硬化性全脑炎（SSPE）患者中，研究了对持续和急性感染麻疹病毒的LU106（异倍体人肺细胞系）细胞的自发细胞毒性。还使用K562（髓细胞系）细胞来检测自然杀伤（NK）活性。对于持续和急性感染麻疹的LU106细胞，麻疹免疫和非免疫供体的特异性细胞毒性反应没有显著差异，这表明我们的检测系统检测到了NK活性。分别在3例和5例SSPE患者中发现，其针对病毒感染细胞和K562细胞的细胞毒性反应在正常范围内。
