Gabriele F, Ecca A R, Aru A B, Palmas C
Boll Ist Sieroter Milan. 1985;64(5):408-13.
Mice immunized with antigens derived from Trichinella spiralis muscle larvae or Hymenolepis nana embryos were found to be protected against the homologous challenge infection. Intraperitoneal route was found the most effective in stimulating protection compared with subcutaneous or intravenous administration. Even a single dose of antigen administered intraperitoneally stimulated a significant protection. The results of our experiments confirm that the route of administration has a noteworthy influence on the effectiveness of the immunization. The possible mechanism involved in rejection of both worms population are discussed.
用旋毛虫肌幼虫或微小膜壳绦虫胚胎衍生抗原免疫的小鼠，被发现可抵御同源攻击感染。与皮下或静脉给药相比，腹腔途径被发现是刺激产生保护作用最有效的途径。即使腹腔内注射单剂量抗原也能刺激产生显著的保护作用。我们的实验结果证实给药途径对免疫效果有显著影响。文中还讨论了两种虫体群体被排斥可能涉及的机制。
