Pearson M G, Ahmad D, Chamberlain M J, Morgan W K, Vinitski S
Br J Clin Pharmacol. 1985 Dec;20(6):688-90. doi: 10.1111/j.1365-2125.1985.tb05130.x.
Were aminophylline to improve mucociliary function, it might prove useful in the management of irreversible airflow limitation. Eight subjects with irreversible airflow limitation due to emphysema inhaled an aerosol of 99mTc sulphur-colloid particles on each of 2 days. On day 1 aminophylline was administered intravenously, while on the other nothing was given. Particle clearance was measured by recording posterior gamma-camera images sequentially over a 24 h period. No significant differences were recorded between aminophylline and control studies, but there were marked variations in clearance between study days and between individuals. These differences were compatible with the known effects of airways obstruction and breathing pattern on the sites of particle deposition within the bronchial tree. The latter factors appeared to exert a far greater influence on the observed mucociliary clearance than did aminophylline.
如果氨茶碱能改善黏液纤毛功能，那么它可能在不可逆气流受限的治疗中发挥作用。8名因肺气肿导致不可逆气流受限的受试者在两天中的每一天都吸入了99mTc硫胶体颗粒气雾剂。第一天静脉注射氨茶碱，另一天则不给予任何药物。通过在24小时内连续记录后位γ相机图像来测量颗粒清除率。氨茶碱组和对照组研究之间未记录到显著差异，但研究日之间和个体之间的清除率存在明显差异。这些差异与气道阻塞和呼吸模式对支气管树内颗粒沉积部位的已知影响相符。与氨茶碱相比，后述因素似乎对观察到的黏液纤毛清除率影响更大。
