Takemura Yuta, Inoue Kosuke, Sato Koryu, Haseda Maho, Shiba Koichiro, Kondo Naoki
Tokyo Bay Urayasu Ichikawa Medical Center, Chiba, Japan.
Department of Social Epidemiology, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan.
JAMA Netw Open. 2025 Sep 2;8(9):e2530523. doi: 10.1001/jamanetworkopen.2025.30523.
Previous studies have suggested that social participation helps prevent depression among older adults. However, evidence is lacking about whether the preventive benefits vary among individuals and who would benefit most.
To examine the sociodemographic, behavioral, and health-related heterogeneity in the association between social participation and depressive symptoms among older adults and to identify the individual characteristics among older adults expected to benefit the most from social participation.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study included participants aged 65 years or older in the 2016, 2019, and 2022 waves of the Japan Gerontological Evaluation Study (JAGES), a nationwide survey examining social determinants of health and social environment in Japan. All participants were functionally and cognitively independent. Analyses were performed from February 2024 to February 2025.
Social participation recorded in the 2019 JAGES. Participation included involvement in hobby groups, sports groups or clubs, volunteer clubs, senior citizen clubs, and neighborhood communities more often than once a month.
The main outcome was depressive symptoms defined as a score of 5 or higher on the Geriatric Depression Scale (GDS; score range: 0-15, with higher scores indicating more severe depressive symptoms) in the 2022 JAGES. After 1:1 propensity score matching on the status of social participation in the 2019 JAGES to adjust for characteristics in the 2016 JAGES, a machine learning-based causal forest algorithm was used to assess the heterogeneity in the association between social participation and depressive symptoms. Conditional average treatment effect (CATE) was estimated for each individual, and the median of the CATE distribution was used as a threshold to categorize participants by their characteristics into the high-benefit group or low-benefit group.
Among the 11 146 propensity score-matched older individuals (mean [SD] age, 72.40 (5.15) years; 5762 men [51.7%]; 15.7% developed depressive symptoms), social participation was associated with reduction in the risk of depressive symptoms (2.2 [95% CI, 0.9-3.5] percentage points). The causal forest model showed heterogeneity across individual characteristics. Compared with the low-benefit group, the high-benefit group were more likely to be older and have lower socioeconomic status (lower educational level and household income). The reduction in risk of depressive symptoms associated with social participation was observed in the high-benefit group (4.1 [95% CI, 1.3-6.9] percentage points) but not in the low-benefit group (0.4 [95% CI, -2.0 to 2.8] percentage points).
In this cohort study, the association between social participation and depressive symptoms varied across individual characteristics. Promoting social participation, particularly for older adults with lower socioeconomic status, would play a role in not only improved mental health but also decreased mental health disparities during the global population aging.
先前的研究表明,社会参与有助于预防老年人抑郁。然而,关于预防益处是否因人而异以及谁将从中受益最大,目前尚缺乏证据。
探讨老年人社会参与与抑郁症状之间关联中的社会人口学、行为及健康相关异质性,并确定最有望从社会参与中获益的老年人个体特征。
设计、背景与参与者:这项队列研究纳入了2016年、2019年和2022年日本老年学评估研究(JAGES)三轮调查中65岁及以上的参与者,JAGES是一项针对日本健康和社会环境的社会决定因素的全国性调查。所有参与者在功能和认知方面均独立。分析于2024年2月至2025年2月进行。
2019年JAGES记录的社会参与情况。参与包括每月不止一次地参与兴趣小组、体育团体或俱乐部、志愿者俱乐部、老年俱乐部以及邻里社区。
主要结局为抑郁症状,定义为2022年JAGES中老年抑郁量表(GDS;评分范围:0 - 15,分数越高表明抑郁症状越严重)得分达到5分或更高。在根据2019年JAGES中的社会参与状况进行1:1倾向得分匹配以调整2016年JAGES中的特征后,使用基于机器学习的因果森林算法评估社会参与与抑郁症状之间关联的异质性。为每个个体估计条件平均治疗效应(CATE),并将CATE分布的中位数用作阈值,根据参与者特征将其分为高受益组或低受益组。
在11146名倾向得分匹配的老年人中(平均[标准差]年龄为72.40(5.15)岁;5762名男性[51.7%];15.7%出现抑郁症状),社会参与与抑郁症状风险降低相关(2.2[95%置信区间,0.9 - 3.5]个百分点)。因果森林模型显示个体特征存在异质性。与低受益组相比,高受益组更可能年龄较大且社会经济地位较低(教育水平和家庭收入较低)。在高受益组中观察到社会参与与抑郁症状风险降低相关(4.1[95%置信区间,1.3 - 6.9]个百分点),而在低受益组中未观察到(0.4[95%置信区间, - 2.0至2.8]个百分点)。
在这项队列研究中,社会参与与抑郁症状之间的关联因个体特征而异。促进社会参与,特别是对于社会经济地位较低的老年人,不仅有助于改善心理健康,还能在全球人口老龄化过程中减少心理健康差异。