Sun Xiaoyuan, He Xiaoyan, Wang Linhua, Wang Fengmei, Yang Yue
Obstetrics and Gynecology, Civil Aviation General Hospital, Beijing, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e44204. doi: 10.1097/MD.0000000000044204.
This study aims to elucidate the relationship between the triglyceride-glucose index (TyG) index and perimenopausal abnormal uterine bleeding (AUB) risk. A total of 306 patients diagnosed with perimenopausal AUB at our hospital between January 2022 and December 2023 were enrolled. Using a TyG index cutoff of 0.4, participants were divided into 2 groups: a high TyG index group (≥0.4, n = 153) and a low TyG index group (<0.4, n = 153).General clinical data, including body mass index, albumin, C-reactive protein, total protein, creatinine, serum triglycerides, fasting glucose, and TyG index, were compared between the groups. Statistical analyses were performed to evaluate the association between the TyG index and perimenopausal AUB. The study was approved by Civil Aviation General Hospital Ethics Committee (no. CAGH-2021-056), and informed consent was obtained from all participants. Significant differences were observed between the 2 groups in body mass index, albumin, C-reactive protein, total protein, creatinine, serum triglycerides, fasting glucose, bleeding duration, and TyG index (P < .05). A higher TyG index was associated with an increased risk of perimenopausal AUB (P < .05). Subgroup analyses revealed correlations between the TyG index and age ≥ 55 years, obesity, diabetes, tumor history, arthritis, stroke, thyroid disorders, and heart failure (P < .05). Notably, a nonlinear relationship was identified: when the TyG index was below 0.4, a higher index correlated with reduced AUB risk; conversely, a TyG index above 0.4 was linked to elevated AUB risk (P < .05). The TyG index is significantly associated with perimenopausal AUB, with higher values indicating increased risk. This index may serve as a predictive marker for assessing AUB risk in perimenopausal women, highlighting its potential clinical utility in early intervention and management strategies.
本研究旨在阐明甘油三酯-葡萄糖指数（TyG指数）与围绝经期异常子宫出血（AUB）风险之间的关系。2022年1月至2023年12月期间，我院共纳入306例诊断为围绝经期AUB的患者。采用TyG指数临界值0.4，将参与者分为两组：高TyG指数组（≥0.4，n = 153）和低TyG指数组（<0.4，n = 153）。比较两组之间的一般临床数据，包括体重指数、白蛋白、C反应蛋白、总蛋白、肌酐、血清甘油三酯、空腹血糖和TyG指数。进行统计分析以评估TyG指数与围绝经期AUB之间的关联。本研究经民航总医院伦理委员会批准（编号：CAGH-2021-056），并获得所有参与者的知情同意。两组在体重指数、白蛋白、C反应蛋白、总蛋白、肌酐、血清甘油三酯、空腹血糖、出血持续时间和TyG指数方面存在显著差异（P < 0.05）。较高的TyG指数与围绝经期AUB风险增加相关（P < 0.05）。亚组分析显示TyG指数与年龄≥55岁、肥胖、糖尿病、肿瘤病史、关节炎、中风、甲状腺疾病和心力衰竭之间存在相关性（P < 0.05）。值得注意的是，发现了一种非线性关系：当TyG指数低于0.4时，较高的指数与AUB风险降低相关；相反，TyG指数高于0.4与AUB风险升高相关（P < 0.05）。TyG指数与围绝经期AUB显著相关，值越高表明风险越高。该指数可作为评估围绝经期女性AUB风险的预测标志物，突出其在早期干预和管理策略中的潜在临床应用价值。
