MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
EBioMedicine. 2022 Oct;84:104238. doi: 10.1016/j.ebiom.2022.104238. Epub 2022 Sep 5.
Abnormal Uterine Bleeding (AUB) is a common debilitating condition that significantly reduces quality of life of women across the reproductive age span. AUB creates significant morbidity, medical, social, and economic problems for women, their families, workplace, and health services. Despite the profoundly negative effects of AUB on public health, advancement in understanding the pathophysiology of AUB and the discovery of novel effective therapies is slow due to lack of reliable pre-clinical models. This review discusses currently available laboratory-based pre-clinical scientific models and how they are used to study AUB. Human and animal in vitro, ex vivo, and in vivo models will be described along with advantages and limitations of each method.
异常子宫出血（AUB）是一种常见的使人虚弱的病症，严重降低了育龄期妇女的生活质量。AUB 给女性、她们的家庭、工作场所和医疗服务带来了重大的发病、医疗、社会和经济问题。尽管 AUB 对公共健康有深远的负面影响，但由于缺乏可靠的临床前模型，人们对 AUB 的病理生理学的理解和新的有效治疗方法的发现进展缓慢。这篇综述讨论了目前可用的基于实验室的临床前科学模型，以及它们如何用于研究 AUB。将描述人类和动物的体外、离体和体内模型，以及每种方法的优点和局限性。
