Hubbard J D, Pugh J L, Berlin S A, Janssen H F
Circ Shock. 1985;17(4):339-48.
Injection of E. coli endotoxin in dogs promotes hemodynamic changes in circulating blood volume and blood components. Adult mongrel dogs were given endotoxin and studied for 3 hours. Red-blood-cell (RBC) volume and whole-blood volume was measured using the Cr-51 RBC labeling method. Hematocrit and RBC counts were taken at various time periods. Whole-blood volume was not found to change significantly over the test period; however, plasma volume demonstrated a significant decrease by 60 minutes with a parallel increase in RBC volume. Hematocrit increased significantly by 60 minutes and continued its rise to a 30% increase at 3 hours. Circulating RBC counts demonstrated a 26% increase. RBC precursors such as reticulocytes and normoblasts were counted using standard microscopic methods and were observed to increase after injection of endotoxin. These data suggest that the increases in hemoconcentration after administration of endotoxin are caused not only by the loss of plasma from the circulation but also by release of RBCs from blood-forming organs.
给狗注射大肠杆菌内毒素会促使循环血容量和血液成分发生血流动力学变化。对成年杂种狗注射内毒素并进行3小时的研究。使用铬-51红细胞标记法测量红细胞（RBC）容量和全血容量。在不同时间段采集血细胞比容和红细胞计数。在测试期间未发现全血容量有显著变化；然而，血浆容量在60分钟时显著减少，同时红细胞容量平行增加。血细胞比容在60分钟时显著增加，并在3小时时持续上升至增加30%。循环红细胞计数增加了26%。使用标准显微镜方法对网织红细胞和正成红细胞等红细胞前体进行计数，观察到注射内毒素后其数量增加。这些数据表明，内毒素给药后血液浓缩的增加不仅是由于循环中血浆的丢失，还由于造血器官释放红细胞所致。
