Sneek J H, Eijzenbach V, Ligtenberg A C, Borst C
Clin Exp Pharmacol Physiol. 1985 Jul-Aug;12(4):365-72. doi: 10.1111/j.1440-1681.1985.tb00884.x.
A measuring system is described for the long-term continuous beat-to-beat measurement of mean aortic pressure and heart period (interval between beats) in the conscious unrestrained rabbit. Pressures and heart periods were collected in hourly histograms. The histograms were summed into day (0800-2000 h), night (2000-0800 h) and 24-hour histograms. Separate histograms were formed for resting and active periods. From each histogram the mean value, standard deviation, fifth percentile, 50th percentile and 95th percentile were calculated and stored on a floppy disc together with the histograms. Off-line, histograms and their descriptive parameters were plotted and sent to a HP1000 computer for bulk storage and further analysis. The measuring system is capable of handling up to eight animals simultaneously for an indefinite period. The design functioned properly in the long-term measurement (more than 4 weeks) of mean level and variability of arterial pressure and heart period. The measuring system is useful in the study of arterial blood pressure behaviour after sino-aortic denervation and in the evaluation of drug effects in conscious animals.
本文描述了一种用于长期连续逐搏测量清醒、未束缚家兔平均主动脉压和心动周期（心搏间期）的测量系统。压力和心动周期以每小时的直方图形式收集。这些直方图被汇总成天（08:00 - 20:00）、夜（20:00 - 08:00）和24小时的直方图。为静息期和活动期分别形成直方图。从每个直方图中计算出平均值、标准差、第5百分位数、第50百分位数和第95百分位数，并与直方图一起存储在软盘上。离线时，绘制直方图及其描述性参数，并发送到HP1000计算机进行大容量存储和进一步分析。该测量系统能够同时无限期地处理多达八只动物。该设计在动脉压和心动周期的平均水平及变异性的长期测量（超过4周）中运行正常。该测量系统可用于研究窦主动脉去神经后动脉血压行为以及评估清醒动物的药物作用。
