Sreng Syna, Chung Joey, Toh Angeline, Zhen Yvonne Ng Bei, Eppenberger Leila Sara, Chua Jacqueline, Hoang Quan V, Chong Rachel S, Tan Anna C S, Schmetterer Leopold, Ang Marcus, Wong Damon
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
SERI-NTU Advanced Ocular Engineering (STANCE) Program, Singapore, Singapore.
Invest Ophthalmol Vis Sci. 2025 Sep 2;66(12):21. doi: 10.1167/iovs.66.12.21.
The purpose of this study was to investigate the focal relationship between choroidal thickness and retinal sensitivity in myopic eyes.
Participants underwent swept-source optical coherence tomography (SS-OCT) imaging and microperimetry testing. Choroidal thicknesses were obtained by segmenting the SS-OCT scans using a deep-learning approach. Retinal sensitivity was measured at 33 locations using scotopic microperimetry, and corresponding focal choroidal thickness at these locations were computed. Focal structure-function associations between retinal sensitivity and choroidal thickness across 15 retinal eccentricities were evaluated, and adjusted for retinal thickness, signal strength, age, axial length, and gender.
The analysis included 280 eyes from 155 participants (mean age = 25.8 ± 3.0 years) with myopia with a mean axial length of 26.56 ± 0.99 mm and refractive error of -6.87 ± 2.05 diopters (D). Mean retinal sensitivity was 27.68 ± 1.28 decibels (dB). Mean choroid thickness was 217.85 ± 66.66 µm, with choroidal thickness in the nasal quadrant significantly thinner than in the other quadrants. Choroidal thicknesses were correlated with retinal sensitivity in 14 of 15 retinal regions, including the global eccentricity zone (r = 0.261, P < 0.001). Significant associations were similarly found with retinal thickness (r = 0.305, P < 0.001), age (r = 0.182, P < 0.05), and axial length (r = -0.402, P < 0.001). Focal structure-function models further substantiated these relationships, demonstrating a significant effect size (β = 0.78, 95% confidence interval [CI] = 0.39-1.16, P < 0.001) after adjusting for retinal thickness and other demographic factors.
Significant associations between choroidal thickness measurements and microperimetry were observed in a cross-sectional cohort of myopic eyes, suggesting a structure-function relationship with retinal sensitivity at the choroid. Further studies will be required to evaluate this in other cohorts and in progression.
本研究旨在探讨近视眼脉络膜厚度与视网膜敏感度之间的局部关系。
参与者接受扫频光学相干断层扫描（SS-OCT）成像和微视野计测试。使用深度学习方法对SS-OCT扫描进行分割以获取脉络膜厚度。使用暗视微视野计在33个位置测量视网膜敏感度，并计算这些位置相应的局部脉络膜厚度。评估了15个视网膜离心率下视网膜敏感度与脉络膜厚度之间的局部结构-功能关联，并对视网膜厚度、信号强度、年龄、眼轴长度和性别进行了校正。
分析纳入了155名参与者的280只眼（平均年龄=25.8±3.0岁），这些参与者患有近视眼，平均眼轴长度为26.56±0.99毫米，屈光不正为-6.87±2.05屈光度（D）。平均视网膜敏感度为27.68±1.28分贝（dB）。平均脉络膜厚度为217.85±66.66微米，鼻侧象限的脉络膜厚度明显薄于其他象限。在15个视网膜区域中的14个区域，脉络膜厚度与视网膜敏感度相关，包括整体离心率区域（r=0.261，P<0.001）。同样发现与视网膜厚度（r=0.305，P<0.001）、年龄（r=0.182，P<0.05）和眼轴长度（r=-0.402，P<0.001）存在显著关联。局部结构-功能模型进一步证实了这些关系，在对视网膜厚度和其他人口统计学因素进行校正后，显示出显著的效应量（β=0.78，95%置信区间[CI]=0.39-1.16，P<0.001）。
在一个近视眼横断面队列中观察到脉络膜厚度测量值与微视野计之间存在显著关联，提示脉络膜与视网膜敏感度之间存在结构-功能关系。需要进一步的研究在其他队列和疾病进展过程中对此进行评估。
