胎儿和衰老大鼠若干个体组织中的蛋白质周转与组织蛋白酶B活性

Protein turnover and cathepsin B activity in several individual tissues of foetal and senescent rats.

作者信息

Goldspink D F, Lewis S E, Kelly F J

出版信息

Comp Biochem Physiol B. 1985;82(4):849-53. doi: 10.1016/0305-0491(85)90534-6.

Abstract

The fractional rate of protein synthesis has been measured in vivo, and compared in the whole body and 12 major individual tissues of foetal and senescent rats. This synthetic rate was found to decrease in most tissues with increasing animal age. The rate of protein degradation was also determined and compared with cathepsin B activity within each tissue; both protein turnover and the endopeptidase activity decreased with ageing. Age-related changes in each tissue's contributions to the protein mass and synthetic rates of the whole animal are also summarized and related to developmental variations in physiological function.

摘要

已在体内测量了蛋白质合成的分数率，并在胎儿和衰老大鼠的全身及12个主要个体组织中进行了比较。发现随着动物年龄的增加，大多数组织中的这种合成率会降低。还测定了蛋白质降解率，并与每个组织中的组织蛋白酶B活性进行了比较；蛋白质周转率和内肽酶活性均随衰老而降低。还总结了每个组织对整个动物蛋白质质量和合成率贡献的与年龄相关的变化，并将其与生理功能的发育变化相关联。