Schaub Jennifer A, Alaba Mathew, Kretzler Matthias
Division of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI.
Division of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI.
Semin Nephrol. 2025 Sep 8:151663. doi: 10.1016/j.semnephrol.2025.151663.
Despite intensive research efforts, acute kidney injury (AKI) is a common clinical syndrome that has limited treatment options apart from supportive care. The increasing availability of molecular interrogation data from patients with Acute Kidney Injury provides an unparalleled opportunity to leverage systems biology approaches. In this review, we discuss the challenges with AKI research, explain how systems biology approaches can link molecular data to clinical phenotypes, review available molecular interrogation tools and techniques, and provide examples where systems biology approaches have been successfully applied in nephrology. Semin Nephrol 36:x-xx © 20XX Elsevier Inc. All rights reserved.
尽管进行了深入的研究，但急性肾损伤（AKI）仍是一种常见的临床综合征，除了支持性治疗外，治疗选择有限。急性肾损伤患者分子检测数据的日益增多，为利用系统生物学方法提供了前所未有的机会。在本综述中，我们讨论了AKI研究面临的挑战，解释了系统生物学方法如何将分子数据与临床表型联系起来，回顾了可用的分子检测工具和技术，并提供了系统生物学方法在肾脏病学中成功应用的实例。《肾脏病学研讨会》36:x-xx © 20XX爱思唯尔公司。保留所有权利。
