Lagerlöf R K, Tone J N
Drug Chem Toxicol. 1985;8(6):469-82. doi: 10.3109/01480548509041070.
The effects of gossypol acetic acid (GAA) on various aspects of female rat reproduction were evaluated. Forty sexually mature, nulliparous female Holtzman rats received a daily, oral dose of GAA (20 mg GAA/Kg body wt) for 60 days. Nineteen control animals were utilized. Throughout the treatment period, GAA treated rats had significantly more irregular estrous cycles than did controls, and the mean duration of an estrous cycle in the GAA rats was significantly longer than that of controls. A significantly lower body weight gain was observed in all GAA treated animals. A prolonged time for mating, a decrease in incidence of pregnancy, and a reduction in number of viable embryos at Day 13 of gestation were noted among GAA treated animals. Weaning weights of offspring from GAA dams were significantly less than weaning weights of offspring from control dams.
评估了醋酸棉酚（GAA）对雌性大鼠生殖各个方面的影响。40只性成熟、未生育的雌性霍尔茨曼大鼠每天口服GAA（20毫克GAA/千克体重），持续60天。使用了19只对照动物。在整个治疗期间，GAA处理的大鼠发情周期明显比对照组更不规律，且GAA处理大鼠的发情周期平均持续时间明显长于对照组。在所有接受GAA处理的动物中均观察到体重增加显著降低。在接受GAA处理的动物中，交配时间延长、怀孕发生率降低以及妊娠第13天存活胚胎数量减少。GAA处理母鼠所产后代的断奶体重明显低于对照母鼠所产后代的断奶体重。
