Pan L C, Nadakavukaren M J, Jensen D R
Department of Biological Sciences, Illinois State University, Normal 61761.
Cell Tissue Res. 1987 Oct;250(1):215-20. doi: 10.1007/BF00214674.
Ultrastructural changes were observed in the oocytes and granulosa cells of the ovarian follicles of sexually mature female rats treated daily for 60 days with gossypol acetic acid at a dosage known to induce sterility in male rats (20 mg/kg body weight, orally). The changes included an increased lysosomal population in the ooplasm and a reduced, poorly developed smooth endoplasmic reticulum in the granulosa cells. The latter changes suggest a suppression of the secretory activity of the granulosa cells.
