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伴有囊性成分的毛细血管扩张性骨肉瘤的分子形态学:一例报告

Molecular Morphology of Telangiectatic Osteosarcoma Associated With Сystic Content: A Case Report.

作者信息

Makaridze David, Mariamidze Armaz, Gvianishvili Tamuna, Ottaviani Giulia, Gogiashvili Liana

机构信息

Histology and Embryology, David Tvildiani Medical University, Tbilisi, GEO.

Pathology, David Tvildiani Medical University, Tbilisi, GEO.

出版信息

Cureus. 2025 Aug 8;17(8):e89658. doi: 10.7759/cureus.89658. eCollection 2025 Aug.

Abstract

This case report is focused on a patient (a 32-year-old previously healthy man) with a femoral bone tissue tumor. The case underscores the diagnostic complexity of Telangiectatic Osteosarcoma (TOS) with Aneurysmal Bone Cystic (ABC) lesion and the importance of maintaining special immunohistochemical markers for differential diagnosis between low-grade osteosarcoma, primary ABC, and suspected TOS, which is a true mimicker of ABC. On the other hand, this presentation describes some molecular rearrangements seen in ABC.

摘要

本病例报告聚焦于一名患有股骨骨组织肿瘤的患者(一名32岁既往健康的男性)。该病例强调了伴有动脉瘤样骨囊肿(ABC)病变的毛细血管扩张性骨肉瘤(TOS)的诊断复杂性,以及保留特殊免疫组化标志物对于鉴别低级别骨肉瘤、原发性ABC和疑似TOS(ABC的真正模仿者)的重要性。另一方面,本报告描述了在ABC中观察到的一些分子重排。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72b0/12415300/91bd33689ee9/cureus-0017-00000089658-i01.jpg

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