Warraich Muhammad Usman Tufail, Shafqat Muhammad Nabeel, Ajmal Usman, Choudhary Muhammad Adil, Shaukat Ayesha, Saleem Nabeel, Affan-Ud-Din Muhammad, Khaliq Namra, Yaseen Adeel, Riaz Hamza
Gastroenterology and Hepatology, Queen Alexandra Hospital, Portsmouth, GBR.
Internal Medicine, Three Crosses Regional Hospital, Las Cruces, USA.
Cureus. 2025 Aug 8;17(8):e89617. doi: 10.7759/cureus.89617. eCollection 2025 Aug.
Many published studies have shown that the prevalence of celiac disease (CD) is higher in individuals with irritable bowel syndrome (IBS); however, the current available evidence is controversial. Moreover, controversy exists regarding the routine screening of CD in IBS patients, as the available results show conflicting evidence. Objective: This study aimed to determine the prevalence of CD in individuals with IBS presenting at a tertiary care hospital.
This one-year cross-sectional study was performed at District Headquarters (DHQ) Teaching Hospital, Gujranwala, Pakistan, between January 2019 and January 2020. A total of 260 persons, who fulfilled the inclusion and exclusion criteria, were selected through a non-probability consecutive sampling technique. Patients having positive anti-tissue transglutaminase (anti-TTG) IgA and IgG antibodies were diagnosed as having probable celiac disease (PCD). Data were collected and compiled using IBM SPSS Statistics for Windows, Version 23.0 (IBM Corp., Armonk, New York, United States). Post-stratification, the chi-squared test was applied, taking p≤0.05 as significant.
The mean age of the patients was 49.4±18.5 years. Gender distribution showed that 168 (64.6%) were males, while 92 (35.4%) were females. Among 260 patients, 39 (15%) were diagnosed with CD. Duration of IBS is associated with increased prevalence of CD, and this association is statistically significant (p<0.001). Conclusion: Patients with IBS, irrespective of age and gender, are more susceptible to develop CD compared to the general population. Based on these findings, we recommend routine screening for CD with serologic markers in all IBS patients to identify individuals with latent or potential CD.
许多已发表的研究表明，肠易激综合征（IBS）患者中乳糜泻（CD）的患病率较高；然而，目前可得的证据存在争议。此外，对于IBS患者常规筛查CD也存在争议，因为现有结果显示证据相互矛盾。目的：本研究旨在确定在一家三级护理医院就诊的IBS患者中CD的患病率。
本为期一年的横断面研究于2019年1月至2020年1月在巴基斯坦古杰兰瓦拉地区总部（DHQ）教学医院进行。通过非概率连续抽样技术共选取了260名符合纳入和排除标准的人员。抗组织转谷氨酰胺酶（抗TTG）IgA和IgG抗体呈阳性的患者被诊断为可能患有乳糜泻（PCD）。使用IBM SPSS Statistics for Windows 23.0版（IBM公司，美国纽约州阿蒙克）收集和整理数据。分层后，应用卡方检验，以p≤0.05为有统计学意义。
患者的平均年龄为49.4±18.5岁。性别分布显示，168名（64.6%）为男性，而92名（35.4%）为女性。在260名患者中，39名（15%）被诊断为患有CD。IBS的病程与CD患病率增加相关，且这种关联具有统计学意义（p<0.001）。结论：与普通人群相比，IBS患者无论年龄和性别，都更容易患CD。基于这些发现，我们建议对所有IBS患者进行血清学标志物的CD常规筛查，以识别潜在或隐匿性CD患者。
