Xi Changmeng, Sun Qingshan, Xu Jiaxi
State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
Beilstein J Org Chem. 2025 Sep 4;21:1786-1790. doi: 10.3762/bjoc.21.140. eCollection 2025.
Both chiral bisoxazolines and bisimidazolines are efficient chiral ligands in metal-catalyzed asymmetric organic transformations. Chiral cyclohexane-linked bisimidazolines were prepared from optically active cyclohexane-1,2-dicarboxylic acid and 1,2-diphenylethane-1,2-diamines via the monosulfonylation of 1,2-diphenylethane-1,2-diamines, condensation of -sulfonylated 1,2-diphenylethane-1,2-diamines and cyclohexane-1,2-dicarboxylic acid, and the final cyclization with the in situ generated Hendrickson reagent.
手性双恶唑啉和双咪唑啉在金属催化的不对称有机转化中都是高效的手性配体。手性环己烷连接的双咪唑啉是由光学活性的环己烷-1,2-二羧酸和1,2-二苯基乙烷-1,2-二胺通过1,2-二苯基乙烷-1,2-二胺的单磺酰化、磺酰化的1,2-二苯基乙烷-1,2-二胺与环己烷-1,2-二羧酸的缩合，以及最终与原位生成的亨德里克森试剂环化制备而成。
