Kawamoto K, Kawashima S
Exp Gerontol. 1985;20(5):295-304. doi: 10.1016/0531-5565(85)90056-7.
Changes of magnocellular neurons after hypophysectomy were immunohistochemically studied using antisera to arginine vasopressin (AVP) and oxytocin (OXT) in young and old female mice of the C57BL/Tw strain. AVP-immunoreactive neurons in the supraoptic and paraventricular nuclei of intact 19-month-old mice showed a marked reduction in number and immunoreactivity as compared with those of intact 3-month-old mice. Age difference of OXT-immunoreactive neurons was less pronounced than that of AVP-immunoreactive neurons. After hypophysectomy, both AVP- and OXT-immunoreactive neurons showed an intense stainability 10 days after the operation regardless of ages. However, the rate of reduction in number of immunoreactive neurons after hypophysectomy was less marked in 19-month-old than 3-month-old mice.
利用抗精氨酸加压素（AVP）和催产素（OXT）的抗血清，通过免疫组织化学方法研究了C57BL/Tw品系年轻和老年雌性小鼠垂体切除术后大细胞神经元的变化。与3个月大的完整小鼠相比，19个月大的完整小鼠视上核和室旁核中AVP免疫反应性神经元的数量和免疫反应性明显减少。OXT免疫反应性神经元的年龄差异不如AVP免疫反应性神经元明显。垂体切除术后，无论年龄大小，AVP和OXT免疫反应性神经元在术后10天均表现出强烈的染色性。然而，垂体切除术后免疫反应性神经元数量的减少率在19个月大的小鼠中比3个月大的小鼠中不那么明显。
