Chen Chen, Gao Zhengrong, Li Yuman, Zhou Tuanfeng, Zheng Huimin, Jiang Shengjie, Yang Yue, Wei Yan
Department of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
Department of Prosthodontics, The First Clinical Division, Peking University School and Hospital of Stomatology, Beijing 100034, P.R. China.
iScience. 2025 Aug 14;28(9):113353. doi: 10.1016/j.isci.2025.113353. eCollection 2025 Sep 19.
This study highlights the biomedical relevance of injectable TS (tannic acid-silk fibroin)-Mg/Sr hydrogels in alveolar bone repair, particularly their prospective role as carriers for stem cells from the apical papilla (SCAPs) in tissue regeneration. By utilizing self-assembling silk material, noted for its favorable handling properties, we present a useful approach for single-wall bone defects, such as bone fenestration and fractures in the oral cavity. Furthermore, our findings regarding the involvement of the TRPM7 ion channel indicate a possible regulatory pathway for improving alveolar bone defect repair. This study provides a biological and applicational basis for future use in oral and maxillofacial regeneration.
本研究强调了可注射的单宁酸-丝素蛋白（TS）-镁/锶水凝胶在牙槽骨修复中的生物医学相关性，特别是它们作为根尖乳头干细胞（SCAPs）载体在组织再生中的潜在作用。通过利用以良好操作性能著称的自组装丝材料，我们提出了一种针对单壁骨缺损（如口腔中的骨开窗和骨折）的有用方法。此外，我们关于瞬时受体电位阳离子通道亚家族M成员7（TRPM7）离子通道参与情况的研究结果表明了一条改善牙槽骨缺损修复的可能调控途径。本研究为未来在口腔颌面再生中的应用提供了生物学和应用基础。
