Wang Dong, Peng Yi, Li Yuezhan, Kpegah Julius K S K, Chen Shijie
Department of Spine Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
College of Medicine, Nursing and Health Science, School of Medicine, Regenerative Medicine Institute (REMEDI), University of Galway, Galway, Ireland.
Front Mol Biosci. 2023 Jan 4;9:1105540. doi: 10.3389/fmolb.2022.1105540. eCollection 2022.
Osteosarcoma is the malignant tumor with the highest incidence rate among primary bone tumors and with a high mortality rate. The anti-osteosarcoma materials are the cross field between material science and medicine, having a wide range of application prospects. Among them, biological materials, such as compounds from black phosphorous, magnesium, zinc, copper, silver, etc., becoming highly valued in the biological materials field as well as in orthopedics due to their good biocompatibility, similar mechanical properties with biological bones, good biodegradation effect, and active antibacterial and anti-tumor effects. This article gives a comprehensive review of the research progress of anti-osteosarcoma biomaterials.
骨肉瘤是原发性骨肿瘤中发病率最高且死亡率高的恶性肿瘤。抗骨肉瘤材料是材料科学与医学的交叉领域，具有广泛的应用前景。其中，生物材料，如来自黑磷、镁、锌、铜、银等的化合物，因其良好的生物相容性、与生物骨骼相似的力学性能、良好的生物降解效果以及积极的抗菌和抗肿瘤作用，在生物材料领域以及骨科领域受到高度重视。本文对抗骨肉瘤生物材料的研究进展进行了全面综述。
