Exploring tumour-microbe interactions: in vitro and in vivo modelling of Streptococcus bovis-induced colorectal carcinogenesis.

Streptococcus bovis is an opportunistic bacterium consistently associated with colorectal cancer (CRC). This article reviews previous experimental evidence that has successfully demonstrated the role of S. bovis species in the context of CRC. The emerging evidence from experimental studies shows that the development of CRC involves synergistic mechanisms. This includes microbial dysbiosis or bacterial factors, evasion of the host immune system leading to chronic inflammatory responses, and alterations in cellular signalling pathways, which together promote tumour development and progression. The review may contribute to a better understanding of the role of S. bovis in CRC and its potential as a microbial biomarker and cancer therapeutic target.