扰乱胶质母细胞瘤异质性及其他情况下的神经干细胞命运。
Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond.
作者信息
Hollingsworth Ethan W, Imitola Jaime
机构信息
Medical Scientist Training Program, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Laboratory of Neural Stem Cells and Functional Neurogenetics, Farmington, CT 06030, USA; Departments of Neuroscience, Neurology, Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
出版信息
Stem Cell Reports. 2025 Sep 9;20(9):102633. doi: 10.1016/j.stemcr.2025.102633.
Intratumoral heterogeneity in glioblastoma is thought to underlie its remarkable ability to recur and resist therapies. Its origins, however, remain unknown. In this issue, Liu et al. model the contributions of cell-of-origin and genetic drivers to intratumoral heterogeneity in glioblastoma, using a perturbation paradigm with broad neurodevelopmental applications.
胶质母细胞瘤中的肿瘤内异质性被认为是其复发和抵抗治疗能力显著的基础。然而，其起源仍然未知。在本期中，刘等人使用具有广泛神经发育应用的扰动范式，模拟了起源细胞和基因驱动因素对胶质母细胞瘤肿瘤内异质性的影响。
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