Thanou Irini, Koutsoudaki Paraskevi N, Margariti Maria, Luzzati Federico, Havaki Sophia, Gorgoulis Vassilis G, Thomaidou Dimitra
Neural Stem Cells and Neuroimaging Group, Department of Neurobiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Stem Cell Reports. 2025 Sep 9;20(9):102636. doi: 10.1016/j.stemcr.2025.102636.
In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiation potential and guiding progeny to injured areas. Our study provides evidence of alternative migration pathways for newborn neurons in the mouse subcortical forebrain, revealed by administration of a chemotherapeutic agent. This allows a high number of newborn neurons to migrate long distances over an extended period. Notably, a subpopulation of neuroblasts diverts from the canonical SVZ-olfactory bulb (OB) rostral migratory stream toward the striatum (STR), with distinct localization along striatal myelin tracts and through nucleus accumbens (NAc) to the anterior commissure (AC). This neuroblast (NB) rerouting is accompanied by with oligodendrocyte lineage dysregulation and myelin deficits, suggesting a link between ectopic NB presence and observed myelin abnormalities.
在成人大脑中，神经干细胞（NSCs）在特定的神经发生区域持续产生新的神经元。最近的研究揭示了反应性神经发生，即脑损伤会触发神经干细胞的激活，增强其分化潜能并引导子代细胞到达损伤区域。我们的研究提供了证据，表明在小鼠皮质下前脑，通过给予一种化疗药物揭示了新生神经元的替代迁移途径。这使得大量新生神经元能够在较长时间内远距离迁移。值得注意的是，一群神经母细胞从经典的室管膜下区-嗅球（OB）向吻侧迁移流转向纹状体（STR），沿着纹状体髓鞘束并通过伏隔核（NAc）到达前连合（AC）有不同的定位。这种神经母细胞（NB）重新路由伴随着少突胶质细胞谱系失调和髓鞘缺陷，表明异位NB的存在与观察到的髓鞘异常之间存在联系。
