Asano Yujiro, Miyachi Motohiko, Nanri Hinako, Murakami Haruka, Gando Yuko, Nakagata Takashi, Yoshida Tsukasa, Okura Tomohiro, Yamada Yosuke
Doctoral Program in Physical Education, Health and Sport Science, Degree Programs in Comprehensive Human Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Center for Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Settsu, Japan.
Physiol Rep. 2025 Sep;13(17):e70548. doi: 10.14814/phy2.70548.
This study investigated the association between parameters derived from bioelectrical impedance spectroscopy (BIS) and arterial stiffness, as measured using carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) pulse wave velocities. Data from 292 Japanese adults were analyzed. BIS was used to assess the phase angle (PhA), extracellular water to intracellular water ratio (ECW/ICW), and body cell mass-to-free fat mass ratio (BCM/FFM). cfPWV and baPWV were measured using an Omron-Colin device. Multiple linear regression analyses were conducted to examine the associations between BIS parameters and pulse wave velocity, adjusting for age, sex, height, smoking status, history of chronic diseases, and objectively measured physical activity. The results revealed that lower PhA, higher ECW/ICW, and lower BCM/FFM were significantly associated with higher cfPWV, independent of potential confounders. These associations remained significant even after adjusting for appendicular lean mass index. However, no significant associations were found between the BIS parameters and baPWV after controlling for covariates. These findings suggest that BIS-derived parameters reflecting cellular health and body composition are associated with increased arterial stiffness in the central arteries, independent of muscle mass. This association may partly explain the relationship between these parameters and mortality, thereby highlighting the importance of BIS assessment in health promotion. However, future longitudinal studies are needed to confirm these findings.
本研究调查了生物电阻抗光谱法（BIS）得出的参数与动脉僵硬度之间的关联，动脉僵硬度采用颈动脉-股动脉脉搏波速度（cfPWV）和臂-踝脉搏波速度（baPWV）进行测量。对292名日本成年人的数据进行了分析。BIS用于评估相角（PhA）、细胞外水与细胞内水的比率（ECW/ICW）以及身体细胞质量与游离脂肪质量的比率（BCM/FFM）。使用欧姆龙-科林设备测量cfPWV和baPWV。进行了多元线性回归分析，以检验BIS参数与脉搏波速度之间的关联，并对年龄、性别、身高、吸烟状况、慢性病病史和客观测量的身体活动进行了调整。结果显示，较低的PhA、较高的ECW/ICW和较低的BCM/FFM与较高的cfPWV显著相关，且不受潜在混杂因素的影响。即使在对四肢瘦体重指数进行调整后，这些关联仍然显著。然而，在控制协变量后，未发现BIS参数与baPWV之间存在显著关联。这些发现表明，反映细胞健康和身体组成的BIS衍生参数与中心动脉的动脉僵硬度增加相关，与肌肉质量无关。这种关联可能部分解释了这些参数与死亡率之间的关系，从而突出了BIS评估在健康促进中的重要性。然而，需要未来的纵向研究来证实这些发现。
