Kreutzer Andreas, Brovina Rebecca, Lim Daniel, Robertson John Marion
Cook Children's Health Care System - Exercise Respiratory Center, Prosper, Texas, USA.
University of North Texas Health Science Center - Texas College of Osteopathic Medicine, Fort Worth, Texas, USA.
Physiol Rep. 2025 Sep;13(17):e70543. doi: 10.14814/phy2.70543.
Exercise-induced respiratory symptoms limit physical activity and sport performance in adolescents. Etiologies include exercise-induced bronchoconstriction, laryngeal obstruction, dysfunctional breathing, and in rarer cases, large airway obstruction and cardiac pathologies. Accurate diagnosis requires assessment during exercise that elicits the symptoms patients experience in the field. This is particularly important considering that misdiagnosis with asthma is common among those with laryngeal obstruction and leads to ineffective treatment and increased financial burden for patients and families. Continuous laryngoscopy is the gold standard for the evaluation of intermittent upper airway obstruction during exercise. Researchers recently established the feasibility of continuous bronchoscopy during exercise to assess the large airway in adults. We present the case of a 13-year-old female patient reporting dyspnea, chest tightness, and wheezing during exercise. A double aortic arch causing mild fixed tracheal compression did not appear to explain her symptoms. Vascular rings can cause tracheomalacia, another possible source of intermittent obstruction during exercise. We performed continuous bronchoscopy during exercise following continuous laryngoscopy during a cardiopulmonary exercise test. We found exercise-induced laryngeal obstruction and ruled out tracheomalacia and other potential causes. To our knowledge, this was the first continuous bronchoscopy during exercise performed in a pediatric patient worldwide.
运动诱发的呼吸道症状会限制青少年的身体活动和运动表现。病因包括运动诱发的支气管收缩、喉梗阻、呼吸功能障碍,以及在罕见情况下的大气道梗阻和心脏病变。准确诊断需要在运动期间进行评估,以引发患者在实际场景中所经历的症状。鉴于在喉梗阻患者中误诊为哮喘的情况很常见,这会导致治疗无效,并增加患者及其家庭的经济负担,所以这一点尤为重要。连续喉镜检查是评估运动期间间歇性上气道梗阻的金标准。研究人员最近证实了在运动期间进行连续支气管镜检查以评估成人大气道的可行性。我们报告了一名13岁女性患者的病例,她在运动期间出现呼吸困难、胸闷和喘息症状。双主动脉弓导致轻度固定性气管受压似乎无法解释她的症状。血管环可导致气管软化,这是运动期间间歇性梗阻的另一个可能原因。我们在心肺运动试验期间先进行了连续喉镜检查,随后在运动期间进行了连续支气管镜检查。我们发现了运动诱发的喉梗阻,并排除了气管软化和其他潜在原因。据我们所知,这是全球首例在儿科患者中进行的运动期间连续支气管镜检查。