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Critical evaluation of the ProfiLER-02 study design and outcomes.

作者信息

Subbiah Vivek, Kurzrock Razelle

机构信息

Sarah Cannon Research Institute, Nashville, TN, USA.

Genomic Sciences and Precision Medicine Center and Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.

出版信息

Nat Med. 2025 Sep 10. doi: 10.1038/s41591-025-03959-2.

DOI:10.1038/s41591-025-03959-2
PMID:40931035
Abstract
摘要

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本文引用的文献

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Tissue-agnostic cancer therapies: promise, reality, and the path forward.组织非特异性癌症疗法:前景、现状与未来之路。
Nat Commun. 2025 May 29;16(1):4972. doi: 10.1038/s41467-025-60369-1.
2
Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial.广泛基因检测组与有限基因检测组用于指导晚期实体瘤患者治疗的随机对照试验
Nat Med. 2025 May;31(5):1502-1508. doi: 10.1038/s41591-025-03613-x. Epub 2025 Apr 7.
3
Non-small-cell lung cancer.非小细胞肺癌。
Nat Rev Dis Primers. 2024 Sep 26;10(1):71. doi: 10.1038/s41572-024-00551-9.
4
Universal Germline and Tumor Genomic Testing Needed to Win the War Against Cancer: .战胜癌症需要进行全面的生殖系和肿瘤基因组检测:
J Clin Oncol. 2023 Jun 10;41(17):3100-3103. doi: 10.1200/JCO.22.02833. Epub 2023 Mar 17.
5
PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.PD-1 阻断在错配修复缺陷、局部晚期直肠癌中的应用。
N Engl J Med. 2022 Jun 23;386(25):2363-2376. doi: 10.1056/NEJMoa2201445. Epub 2022 Jun 5.
6
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study.癌症患者的分子谱分析可实现个体化联合治疗:I-PREDICT 研究。
Nat Med. 2019 May;25(5):744-750. doi: 10.1038/s41591-019-0407-5. Epub 2019 Apr 22.
7
High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial.高通量基因组学与难治疗的晚期癌症的临床结局:MOSCATO 01 试验结果。
Cancer Discov. 2017 Jun;7(6):586-595. doi: 10.1158/2159-8290.CD-16-1396. Epub 2017 Apr 1.
8
Targeted therapies: What have we learned from SHIVA?靶向治疗:我们从SHIVA研究中学到了什么?
Nat Rev Clin Oncol. 2016 Dec;13(12):719-720. doi: 10.1038/nrclinonc.2016.164. Epub 2016 Oct 11.
9
Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial.基于肿瘤分子谱的分子靶向治疗与晚期癌症的常规治疗(SHIVA):一项多中心、开放标签、概念验证、随机、对照的 2 期临床试验。
Lancet Oncol. 2015 Oct;16(13):1324-34. doi: 10.1016/S1470-2045(15)00188-6. Epub 2015 Sep 3.