Ao Ting, Huang Yingxiu, Zhen Peng, Hu Ming
Department of Infectious Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Front Nutr. 2025 Aug 26;12:1596424. doi: 10.3389/fnut.2025.1596424. eCollection 2025.
Gut microbiota plays a vital role in maintaining human health. The dietary index for gut microbiota (DI-GM), which reflects the diversity of gut microbiota, has not yet been studied for chronic obstructive pulmonary disease (COPD).
This cross-sectional study analyzed data from adult participants in the 1999-2018 National Health and Nutrition Examination Survey. COPD was identified based on self-reported data. The DI-GM was calculated using dietary recall data. Multivariable logistic regression models were employed to assess the association between DI-GM and COPD. To evaluate the robustness of the association, subgroup and sensitivity analyses were applied.
Increased DI-GM was associated with a decreased prevalence of COPD (OR = 0.96; 95% CI, 0.92-0.99; = 0.016). Greater beneficial gut microbiota scores were inversely related to the prevalence of COPD (OR = 0.95; 95% CI, 0.91-1.00; = 0.03). Both unweighted and multiple interpolated logistic regression analyses confirmed that the relationship remained consistent. Subgroup analyses further supported the robustness of the findings.
A negative association was observed between DI-GM and the prevalence of COPD.
肠道微生物群在维持人类健康方面发挥着至关重要的作用。反映肠道微生物群多样性的肠道微生物群饮食指数（DI-GM）尚未针对慢性阻塞性肺疾病（COPD）进行研究。
这项横断面研究分析了1999 - 2018年国家健康与营养检查调查中成年参与者的数据。COPD是根据自我报告的数据确定的。DI-GM是使用饮食回忆数据计算得出的。采用多变量逻辑回归模型评估DI-GM与COPD之间的关联。为评估该关联的稳健性，进行了亚组分析和敏感性分析。
DI-GM升高与COPD患病率降低相关（OR = 0.96；95%CI，0.92 - 0.99；P = 0.016）。更有益的肠道微生物群评分与COPD患病率呈负相关（OR = 0.95；95%CI，0.91 - 1.00；P = 0.03）。未加权和多次插补逻辑回归分析均证实这种关系保持一致。亚组分析进一步支持了研究结果的稳健性。
观察到DI-GM与COPD患病率之间存在负相关。
