Sadeghpour Sonia, Sedgi Fatemeh Maleki, Daneghian Sevana, Adabi Somayyeh Barania, Behroozi-Lak Tahereh, Pashaei Mohammadreza, RasouIi Javad, Valizadeh Rohollah, Ghasemnejad-Berenji Hojat
Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Clin Exp Reprod Med. 2025 Mar;52(1):79-86. doi: 10.5653/cerm.2024.06982. Epub 2024 Aug 1.
This study aimed to explore the ambiguous link between dietary inflammatory indices and sperm parameters. Specifically, it investigated the associations between the dietary inflammatory index (DII) and the energy-adjusted dietary inflammatory index (E-DII) with sperm motility, morphology, and count in men undergoing routine semen analysis.
A cross-sectional study was conducted with 144 men enrolled, where semen samples were collected and evaluated according to the 2010 World Health Organization guidelines. Dietary data were gathered using a 147-item semi-quantitative food frequency questionnaire developed by the researchers. Pearson correlation analysis was employed to assess the relationships of the DII and E-DII with sperm parameters.
The mean DII and E-DII scores were 1.23±1.1 and 0.49±0.43, respectively. The mean values for sperm motility, morphology, and count were 43.08%±19.30%, 78.03%±26.99%, and 48.12±44.41 million, respectively. Both motility (r=-0.353) and count (r=-0.348) were found to be inversely and significantly correlated with DII. Similarly, Pearson correlation tests revealed strong and significant inverse correlations of motility (r=-0.389) and count (r=-0.372) with E-DII.
The findings suggest that a diet with a higher anti-inflammatory potential may be associated with increased sperm count and motility, but not with changes in morphology. Further research is necessary to confirm these findings, elucidate the underlying mechanisms, and identify dietary modifications that could improve male fertility.
本研究旨在探讨饮食炎症指数与精子参数之间的模糊联系。具体而言，研究了饮食炎症指数（DII）和能量调整饮食炎症指数（E-DII）与接受常规精液分析男性的精子活力、形态和数量之间的关联。
进行了一项横断面研究，招募了144名男性，根据2010年世界卫生组织指南收集并评估精液样本。使用研究人员编制的147项半定量食物频率问卷收集饮食数据。采用Pearson相关分析评估DII和E-DII与精子参数之间的关系。
DII和E-DII的平均得分分别为1.23±1.1和0.49±0.43。精子活力、形态和数量的平均值分别为43.08%±19.30%、78.03%±26.99%和48.12±44.41百万。发现活力（r=-0.353）和数量（r=-0.348）均与DII呈显著负相关。同样，Pearson相关检验显示活力（r=-0.389）和数量（r=-0.372）与E-DII呈强显著负相关。
研究结果表明，具有较高抗炎潜力的饮食可能与精子数量和活力增加有关，但与形态变化无关。需要进一步研究以证实这些发现，阐明潜在机制，并确定可改善男性生育能力的饮食调整方法。
