埃弗罗霉素的结构。

The structure of efrotomycin.

作者信息

Dewey R S, Arison B H, Hannah J, Shih D H, Albers-Schönberg G

出版信息

J Antibiot (Tokyo). 1985 Dec;38(12):1691-8. doi: 10.7164/antibiotics.38.1691.

DOI:10.7164/antibiotics.38.1691

Abstract

The antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder. Mass spectral and NMR analyses show that the compound is a glycoside of the known antibiotic aurodox (II), C44H62N2O12. Ozonolysis and hydrolysis of I produced the disaccharide V, 6-deoxy-4-O-(6-deoxy-2,4-di-O-methyl-alpha -L-mannopyranosyl)-3-O-methyl-beta-D-allopyranose. This disaccharide is attached to the 4-hydroxyl group of the hexahydropyran substructure of aurodox via a beta-linkage to C-1 of the allose.

摘要

抗生素埃弗罗霉素（I），化学式为C59H88N2O20，是从耐内酰胺诺卡氏菌培养物中分离得到的一种无定形黄色粉末。质谱和核磁共振分析表明，该化合物是已知抗生素奥多霉素（II），化学式为C44H62N2O12的糖苷。I经臭氧分解和水解产生二糖V，即6-脱氧-4-O-（6-脱氧-2,4-二-O-甲基-α-L-甘露吡喃糖基）-3-O-甲基-β-D-阿洛吡喃糖。该二糖通过与阿洛糖C-1的β-连接与奥多霉素六氢吡喃亚结构的4-羟基相连。