Pradeep Malavika, Cecil Anju, Suresh Nidhita, Govindasamy Rajakumar, Thirumalaivasan Natesan
Department of Periodontics, Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences(SIMATS), Saveetha University, Chennai, 600077, India.
Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, Tamil Nadu, India.
J Oral Biol Craniofac Res. 2025 Nov-Dec;15(6):1408-1414. doi: 10.1016/j.jobcr.2025.08.030. Epub 2025 Aug 29.
Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.
An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.
LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the bacteria test, and microscope imaging.
LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills bacteria easily while also readily up taking cells for potential for Bio-imaging.
The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.
牙髓感染是一个重大的公共卫生问题，需要新的治疗和诊断方法。源自天然来源的碳点（CDs）由于其优异的性能，包括生物相容性和光致发光，作为纳米材料具有巨大潜力。
研究源自荜拨叶的碳点（LCDs）治疗牙髓感染的可能性以及并行的生物成像功能，构成了核心研究目标。
通过水热法制备LCDs，并用傅里叶变换红外光谱仪（FTIR）、扫描电子显微镜-能谱仪（SEM-EDX）和荧光设备检测其性能。他们使用成纤维细胞生长试验、细菌试验和显微镜成像，测试了细胞对LCDs的接受程度以及它们对细菌的抗性和进入细胞的能力。
LCDs促进了成纤维细胞更好的发育，并使牙髓感染的愈合高于先前的治疗标准。活检测试表明，LCD材料能轻松杀死细菌，同时还能轻易摄取细胞用于生物成像。
该研究表明，LCD类型既可以作为牙髓感染修复的药物，也可以作为活体组织观察的工具。我们发现了一种新方法，这将为牙髓感染的管理和医学成像技术带来新的可能性。
