College of Food Science and Engineering, Northwest A&F University, 22 Xinong Rode, Yangling 712100, Shaanxi, China.
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, Henan Province 450001, China; Key Laboratory of Cold Chain Food Processing and Safety Control (Zhengzhou University of Light Industry), Ministry of Education, Zhengzhou 450001, China.
Int J Biol Macromol. 2024 Nov;279(Pt 4):135577. doi: 10.1016/j.ijbiomac.2024.135577. Epub 2024 Sep 11.
Biomacromolecule hydrogels possess excellent mechanical properties and biocompatibility, but their inability to combat bacteria restricts their application in the biomedical field. With the increasing requirements and demands for hydrogel dressings, wound dressings with antibacterial properties of biomacromolecule hydrogels reinforced by adding antibacterial agents have attracted much attention, and related reviews are emerging. In this paper, the advances of biomacromolecule antibacterial hydrogels (including chitosan, sodium alginate, Hyaluronic acid, cellulose and gelatin) were first overviewed, and the antibacterial agents incorporated into hydrogels were classified (including metals and their derivatives, carbon-based materials, and native compounds). A series of performance evaluations of antibacterial hydrogels in the process of promoting wound healing were then reviewed, including basic properties (mechanical, rheological, injectable and self-healing, etc.), in vitro experiments (hemostasis, antibacterial, anti-inflammatory, anti-oxidation, biocompatibility) and in vivo experiments (in vivo model, histomorphology analysis, cytokines). Finally, the future development of biomacromolecule-based antibacterial hydrogels for wound healing is prospected. This work can provide a useful reference for researchers to prepare practical new wound hydrogel dressings.
生物大分子水凝胶具有优异的机械性能和生物相容性，但它们不能抵抗细菌，这限制了它们在生物医学领域的应用。随着对水凝胶敷料的要求和需求的增加，通过添加抗菌剂来增强生物大分子水凝胶抗菌性能的伤口敷料引起了广泛关注，相关的综述也层出不穷。本文首先概述了生物大分子抗菌水凝胶（包括壳聚糖、海藻酸钠、透明质酸、纤维素和明胶）的进展，并对纳入水凝胶的抗菌剂进行了分类（包括金属及其衍生物、碳基材料和天然化合物）。然后综述了一系列抗菌水凝胶在促进伤口愈合过程中的性能评价，包括基本性能（力学、流变学、可注射性和自修复等）、体外实验（止血、抗菌、抗炎、抗氧化、生物相容性）和体内实验（体内模型、组织形态学分析、细胞因子）。最后，对生物大分子基抗菌水凝胶在伤口愈合方面的未来发展进行了展望。这项工作可为研究人员制备实用的新型伤口水凝胶敷料提供有益的参考。
