STATISTICAL INFERENCE FOR MEAN FUNCTIONS OF COMPLEX 3D OBJECTS.

The use of complex three-dimensional (3D) objects is growing in various applications as data collection techniques continue to evolve. Identifying and locating significant effects within these objects is essential for making informed decisions based on the data. This article presents an advanced nonparametric method for learning and inferring complex 3D objects, enabling accurate estimation of the underlying signals and efficient detection and localization of significant effects. The proposed method addresses the problem of analyzing irregular-shaped 3D objects by modeling them as functional data and utilizing trivariate spline smoothing based on triangulations to estimate the underlying signals. We develop a highly efficient procedure that accurately estimates the mean and covariance functions, as well as the eigenvalues and eigenfunctions. Furthermore, we rigorously establish the asymptotic properties of these estimators. Additionally, a novel approach for constructing simultaneous confidence corridors to quantify estimation uncertainty is presented, and the procedure is extended to accommodate comparisons between two independent samples. The finite-sample performance of the proposed methods is illustrated through numerical experiments and a real-data application using the Alzheimer's Disease Neuroimaging Initiative database.