Song Yue, Zheng Xia, Hu Juan, Ma Subo, Li Kun, Chen Junyao, Xu Xiaoling, Lu Xiaoyang, Wang Xiaojuan
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, China.
The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Microbiol. 2023 Feb 17;14:1083007. doi: 10.3389/fmicb.2023.1083007. eCollection 2023.
The rapid evolution of antibiotic resistance and the complicated bacterial infection microenvironments are serious obstacles to traditional antibiotic therapy. Developing novel antibacterial agents or strategy to prevent the occurrence of antibiotic resistance and enhance antibacterial efficiency is of the utmost importance. Cell membrane-coated nanoparticles (CM-NPs) combine the characteristics of the naturally occurring membranes with those of the synthetic core materials. CM-NPs have shown considerable promise in neutralizing toxins, evading clearance by the immune system, targeting specific bacteria, delivering antibiotics, achieving responsive antibiotic released to the microenvironments, and eradicating biofilms. Additionally, CM-NPs can be utilized in conjunction with photodynamic, sonodynamic, and photothermal therapies. In this review, the process for preparing CM-NPs is briefly described. We focus on the functions and the recent advances in applications of several types of CM-NPs in bacterial infection, including CM-NPs derived from red blood cells, white blood cells, platelet, bacteria. CM-NPs derived from other cells, such as dendritic cells, genetically engineered cells, gastric epithelial cells and plant-derived extracellular vesicles are introduced as well. Finally, we place a novel perspective on CM-NPs' applications in bacterial infection, and list the challenges encountered in this field from the preparation and application standpoint. We believe that advances in this technology will reduce threats posed by bacteria resistance and save lives from infectious diseases in the future.
抗生素耐药性的快速演变以及复杂的细菌感染微环境是传统抗生素治疗的严重障碍。开发新型抗菌剂或策略以防止抗生素耐药性的发生并提高抗菌效率至关重要。细胞膜包覆纳米颗粒（CM-NPs）将天然存在的膜的特性与合成核心材料的特性结合在一起。CM-NPs在中和毒素、逃避免疫系统清除、靶向特定细菌、递送抗生素、实现对微环境的响应性抗生素释放以及根除生物膜方面已显示出相当大的前景。此外，CM-NPs可与光动力、声动力和光热疗法联合使用。在本综述中，简要描述了制备CM-NPs的过程。我们重点关注几种类型的CM-NPs在细菌感染中的功能和应用的最新进展，包括源自红细胞、白细胞、血小板、细菌的CM-NPs。还介绍了源自其他细胞的CM-NPs，如树突状细胞、基因工程细胞、胃上皮细胞和植物来源的细胞外囊泡。最后，我们对CM-NPs在细菌感染中的应用提出了新的观点，并从制备和应用的角度列出了该领域遇到的挑战。我们相信，这项技术的进步将减少细菌耐药性带来的威胁，并在未来拯救因传染病而丧生的生命。
