Li Wei-Qi, Yang Jia-Hua, Liu Lu-Lu, Ding Song-Tao, Yu Bin, Jiang Lin, Yan Ning, Liu Han-Deng
Laboratory of Tissue and Cell Biology, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, China.
College of First Clinical, Chongqing Medical University, Chongqing, China.
Front Aging Neurosci. 2025 Aug 26;17:1580029. doi: 10.3389/fnagi.2025.1580029. eCollection 2025.
Parkinson's disease is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic neurons, leading to significant motor and non-motor symptoms. Recent studies emphasize that exercise is a beneficial intervention, not only helping to decrease the risk of developing of Parkinson's disease but also alleviating existing symptoms. This review investigates the mechanisms by which exercise influences myokines, neurotrophic factors, growth factors, and inflammation-related factors to promote neuronal survival and plasticity in Parkinson's disease. Despite promising findings, the specific molecular pathways through which exercise exerts neuroprotective effects remain largely unexplored, and individual variability in disease progression necessitates personalized exercise interventions tailored to each patient's needs. Furthermore, for patients unable to engage in physical activity, exploring alternative therapies that mimic exercise to achieve neuroprotective effects is crucial. In conclusion, this review highlights the need for further research to elucidate the molecular mechanisms of exercise-induced neuroprotection and to establish effective individualized exercise programs, ultimately improving the management of Parkinson's disease.
帕金森病是一种进行性神经退行性疾病，其特征是多巴胺能神经元变性，导致严重的运动和非运动症状。最近的研究强调，运动是一种有益的干预措施，不仅有助于降低患帕金森病的风险，还能缓解现有症状。本综述研究了运动影响肌动蛋白、神经营养因子、生长因子和炎症相关因子，从而促进帕金森病患者神经元存活和可塑性的机制。尽管有一些有前景的发现，但运动发挥神经保护作用的具体分子途径在很大程度上仍未被探索，而且疾病进展中的个体差异需要根据每个患者的需求制定个性化的运动干预措施。此外，对于无法进行体育活动的患者，探索模拟运动以实现神经保护作用的替代疗法至关重要。总之，本综述强调需要进一步研究，以阐明运动诱导神经保护的分子机制，并建立有效的个性化运动方案，最终改善帕金森病的管理。
