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模拟艾滋病毒传播动态:一种使用NetLogo的基于主体的方法。

Simulating HIV transmission dynamics: An agent-based approach using NetLogo.

作者信息

Amasa Sophia Nicolette C, Beleta Trisha Mae P, Montilla Shemaiah L, Llantos Orven E

机构信息

Department of Computer Science, College of Computer Studies, MSU-Iligan Institute of Technology, Iligan City, Philippines.

出版信息

PLoS One. 2025 Sep 11;20(9):e0330456. doi: 10.1371/journal.pone.0330456. eCollection 2025.

Abstract

Many studies have employed Agent-Based Modeling (ABM) to study the complex dynamics of HIV transmission. However, these studies often focus narrowly on specific subpopulations and limited parameters, restricting the potential of ABM to capture the intricate interrelationships between diverse subpopulations. This paper proposes an improved ABM to simulate HIV epidemic dynamics, exploring parameters such as sexual behaviors, drug use, condom usage, testing frequency, and treatment-seeking behavior. Calibrated with empirical data from the Philippines, the simulation closely aligns with national HIV infection trends from 2010 to 2018, achieving a Mean Absolute Error (MAE) of 3.5 and a Mean Squared Error (MSE) of 14.9. Findings indicate that extended commitment duration, consistent condom use, sexual inactivity, high testing frequencies, and strict adherence to treatment significantly lowers HIV transmission rate. The simulation results mirror trends observed in other studies, suggesting that the enhanced model provides reliable and expected outcomes. The results also illustrate the relationships between different factors, highlighting the model's comprehensive approach. Furthermore, the model effectively captures the trends within a 10-year period, predicting the cyclical rise and fall of new infections every 2 to 3 years, along with the overall decline in the percentage of new infections over time. This paper represents an initial step, prompting further efforts to enhance understanding and public health interventions.

摘要

许多研究都采用基于主体的建模(ABM)来研究艾滋病毒传播的复杂动态。然而,这些研究往往狭隘地聚焦于特定亚群体和有限参数,限制了ABM捕捉不同亚群体之间复杂相互关系的潜力。本文提出一种改进的ABM来模拟艾滋病毒流行动态,探讨性行为、吸毒、避孕套使用、检测频率和寻求治疗行为等参数。通过菲律宾的实证数据进行校准,该模拟与2010年至2018年的全国艾滋病毒感染趋势密切吻合,平均绝对误差(MAE)为3.5,均方误差(MSE)为14.9。研究结果表明,延长承诺持续时间、持续使用避孕套、性活动不活跃、高检测频率以及严格坚持治疗可显著降低艾滋病毒传播率。模拟结果反映了其他研究中观察到的趋势,表明改进后的模型提供了可靠且预期的结果。结果还说明了不同因素之间的关系,突出了该模型的综合方法。此外,该模型有效地捕捉了10年内的趋势,预测新感染病例每2至3年出现周期性的上升和下降,以及随着时间推移新感染病例百分比的总体下降。本文代表了迈出的第一步,促使人们进一步努力加强理解和公共卫生干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c8/12425208/2d6fbfebcabe/pone.0330456.g001.jpg

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