Song Chenning, Li Guangxiao, Tian Yuanmeng, Jing Li, Chen Dong, Wang Weizhong, Shi Yonggang, Wang Dongyu, Li Dongqun, Hao Xinbin, Xing Liying, Liu Shuang
Institute of Preventive Medicine, China Medical University, Shenyang, People's Republic of China.
Department of Chronic Disease, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, People's Republic of China.
J Glob Health. 2025 Sep 12;15:04240. doi: 10.7189/jogh.15.04240.
This study aims to explore the relationship between the Serum uric acid to lymphocyte ratio (ULR) level at admission and the long-term risk of recurrence and death in patients with acute ischemic stroke (AIS) in Liaoning Province.
This multicentre prospective study enrolled 7966 subjects who experienced ischemic stroke (IS) across Liaoning Province, China. The Cox proportional hazards model and Kaplan-Meier curves were used to explore the association of ULR with the risk of recurrence and death in IS.
During a median follow-up period of 4.08 (3.35, 4.43) years, there were 1311 cases of stroke recurrence or death, 1429 cases of cardiovascular (CVD) death, and 910 cases of stroke-cause death. In analysis comparing the Q4 and Q1group, after multivariate adjustment, ULR was significantly positively associated with the incidence of stroke recurrence or death (Q4 vs. Q1: HR = 1.21; 95% CI = 1.04, 1.42), CVD death (Q4 vs. Q1: HR = 1.16; 95% CI = 1.00, 1.34), and stroke-cause death (Q4 vs. Q1: HR = 1.26; 95% CI = 1.05, 1.52). Additionally, the significant correlation between ULR and the risk of IS recurrence or death was partially mediated by diastolic blood pressure (DBP) (8.53%) and systolic blood pressure (SBP) (3.59%) in a positive manner.
This study demonstrates that higher ULR is significantly associated with an increased risk of recurrence and death following IS. The findings suggest that ULR could serve as a valuable prognostic marker in clinical practice, particularly in managing patients with IS.
本研究旨在探讨辽宁省急性缺血性脑卒中（AIS）患者入院时血清尿酸与淋巴细胞比值（ULR）水平与长期复发风险及死亡风险之间的关系。
这项多中心前瞻性研究纳入了中国辽宁省7966例经历过缺血性脑卒中（IS）的受试者。采用Cox比例风险模型和Kaplan-Meier曲线探讨ULR与IS复发风险及死亡风险的关联。
在中位随访期4.08（3.35，4.43）年期间，有1311例卒中复发或死亡病例，1429例心血管疾病（CVD）死亡病例，910例卒中导致的死亡病例。在比较Q4组和Q1组的分析中，经过多变量调整后，ULR与卒中复发或死亡的发生率（Q4 vs. Q1：HR = 1.21；95%CI = 1.04，1.42）、CVD死亡（Q4 vs. Q1：HR = 1.16；95%CI = 1.00，1.34）以及卒中导致的死亡（Q4 vs. Q1：HR = 1.26；95%CI = 1.05，1.52）显著正相关。此外，ULR与IS复发或死亡风险之间的显著相关性部分由舒张压（DBP）（8.53%）和收缩压（SBP）（3.59%）以正向方式介导。
本研究表明，较高的ULR与IS后复发风险和死亡风险增加显著相关。研究结果表明，ULR可作为临床实践中有价值的预后标志物，尤其是在管理IS患者时。
