Zhu Mingang, Wang Yin, Wei Sheng, Chen Guang, Gu Er-Min
Department of Dermatology, The First People's Hospital of Jiashan, Jiashan Hospital Affiliated of Jiaxing University, Jiaxing, 314100, People's Republic of China.
Department of Pathogenic Biology and Immunology, School of Medicine, Taizhou University, Taizhou, 318000, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Sep 5;18:2201-2205. doi: 10.2147/CCID.S550569. eCollection 2025.
Toxic epidermal necrolysis (TEN) is a rare and low incidence rate disease characterized by pirfenidone-induced skin damage. Pirfenidone is a new anti-fibrotic and anti-inflammatory drug that can alleviate the deterioration of lung function in patients with COVID-19-induced pneumonia and prolong the progression-free survival period. However, side effects of pirfenidone have drawn widespread attention, which include gastrointestinal symptoms, liver damage, skin photosensitivity, and rash. So far, many cases caused by pirfenidone have been reported. As far as we know, cases of TEN induced by pirfenidone have rarely been reported. This article presents cases of TEN induced by pirfenidone, so that clinicians can be aware of the possibility of TEN when using pirfenidone, and how to use inflammation-relevant indicators for evaluating the severity and risk of death of TEN, which has potential clinical value.
中毒性表皮坏死松解症（TEN）是一种罕见且发病率低的疾病，其特征为吡非尼酮引起的皮肤损伤。吡非尼酮是一种新型抗纤维化和抗炎药物，可缓解新型冠状病毒肺炎（COVID-19）所致肺炎患者的肺功能恶化，并延长无进展生存期。然而，吡非尼酮的副作用已引起广泛关注，包括胃肠道症状、肝损伤、皮肤光敏性和皮疹。到目前为止，已有许多由吡非尼酮引起的病例报道。据我们所知，由吡非尼酮诱发的TEN病例鲜有报道。本文介绍了由吡非尼酮诱发的TEN病例，以便临床医生在使用吡非尼酮时能够意识到发生TEN的可能性，以及如何使用与炎症相关的指标来评估TEN的严重程度和死亡风险，这具有潜在的临床价值。
