Soka J, Mwimanzi S, Fast C D, Mwesiga G, Edward N, Stephen M, Kondo R, Cox C, Beyene N, Agizew T B
Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO), Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania.
Department of Biology, University of Antwerp, Belgium.
Public Health Action. 2025 Sep 3;15(3):137-139. doi: 10.5588/pha.25.0010. eCollection 2025 Sep.
For over a decade, trained African giant pouched rats have been employed in detecting missed pulmonary TB (PTB). However, the relationship between rat-positive results and subsequent clinical PTB or extrapulmonary TB (EPTB) has not been previously reported. This report highlights the use of rat-positivity as a predictor for PTB clinical diagnosis and treatment among presumptive TB. Treating physicians were 1.39 times more likely to clinically diagnose and treat rat-positives than rat-negatives: 12% versus 9%, respectively, odds ratio=1.39, 95% confidence interval: 1.05-1.84 No difference was observed among EPTB.
十多年来，经过训练的非洲巨囊鼠一直被用于检测漏诊的肺结核（PTB）。然而，此前尚未报道过鼠检测呈阳性结果与随后的临床PTB或肺外结核（EPTB）之间的关系。本报告强调了将鼠检测呈阳性作为推定结核病中PTB临床诊断和治疗预测指标的应用。与鼠检测呈阴性的患者相比，治疗医生对鼠检测呈阳性的患者进行临床诊断和治疗的可能性高1.39倍：分别为12%和9%，比值比=1.39，95%置信区间：1.05-1.84。在EPTB患者中未观察到差异。
