超重人群结直肠癌筛查的长期效益及成本效益评估——中国，2023年
Evaluation of the Long-Term Benefits and Cost-Effectiveness of Colorectal Cancer Screening for Populations with Excess Weight - China, 2023.
作者信息
Xie Jiaxin, Dong Xuesi, Wang Chenran, Zheng Yadi, Luo Zilin, Chen Xiaolu, Guo Zeming, Shi Xiaoyue, Cao Wei, Wang Fei, Li Ni
机构信息
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
China CDC Wkly. 2025 Aug 29;7(35):1132-1137. doi: 10.46234/ccdcw2025.190.
WHAT IS ALREADY KNOWN ON THIS TOPIC?: China has the world's largest population of individuals who are overweight or obese, contributing to the growing burden of colorectal cancer (CRC). Screening is an effective strategy for reducing CRC mortality and incidence.
WHAT IS ADDED BY THIS REPORT?: Using a simulation model, we found that CRC screening reduces incidence and mortality across all body mass index groups (normal, overweight, and obese) in China, with greater quality-adjusted life-year gains and 6%-14% higher colonoscopy efficiency in individuals who are overweight or obese. Screening proved to be more cost-effective for these groups, despite high lifetime healthcare expenditures.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: CRC screening in China can prioritize populations with excess weight and incorporate weight management to improve health outcomes and control long-term healthcare costs.
关于该主题已知的信息有哪些？：中国超重或肥胖人群数量位居世界之首，这导致结直肠癌（CRC）负担日益加重。筛查是降低结直肠癌死亡率和发病率的有效策略。
本报告新增了哪些内容？：通过模拟模型，我们发现结直肠癌筛查可降低中国所有体重指数组（正常、超重和肥胖）的发病率和死亡率，超重或肥胖个体的质量调整生命年获益更大，结肠镜检查效率高6%-14%。尽管终生医疗支出较高，但筛查对这些人群而言更具成本效益。
对公共卫生实践有何启示？：中国的结直肠癌筛查可优先考虑超重人群，并纳入体重管理，以改善健康结果并控制长期医疗成本。
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