Altermatt Aimée, Wilkinson Anna L, Heath Katherine, Jin Defeng, Nguyen Thi, Thomas Alexander J, Ke Tianhui, Zhang Yanqin, Ryan Rebecca E, Gibbs Lisa, Pedrana Alisa, Lusher Dean, Fletcher-Lartey Stephanie, Stoové Mark, Gibney Katherine B, Hellard Margaret
Disease Elimination, Burnet Institute, Melbourne, Victoria, Australia.
School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.
BMJ Public Health. 2025 Sep 8;3(2):e002062. doi: 10.1136/bmjph-2024-002062. eCollection 2025.
It is critical to disseminate all evidence on long COVID's impact on people's lives to inform policy and practice. We aimed to assess five measures of well-being, before and after SARS-CoV-2 infection between people with long COVID (defined as symptoms lasting more than 1 month) and people with short COVID (defined as symptoms resolving within 1 month).
Participants from the Optimise Study, a longitudinal cohort study in Victoria, Australia (September 2020-August 2022), had self-reported history of SARS-CoV-2 infection and self-reported long COVID status. Serial cross-sectional analysis compared participants with long and short COVID on Personal Well-being Index, number of COVID-19-like symptoms experienced, number of days exercised and frequency of experiencing positive and negative emotions.
217 participants were included, aged 20-86 years (median age 43, IQR: 31-57), 75% women. Compared with those with short COVID, participants with long COVID had lower well-being before (mean difference (MD)=-8.3, 95% CI (-14.7, -2.0), p-adjusted=0.07), during (MD=-10.3, 95% CI (-16.5, -4.0), p-adjusted=0.03) and after (MD=-9.91, 95% CI (-16.71, -3.11), p-adjusted=0.05) infection and experienced more COVID-19-like symptoms during infection (MD=1.72 (0.72, 2.72), p-adjusted=0.03). In December 2022, 71% (40/56) reported difficulty performing tasks in the past 4 weeks.
On average, we observed lower well-being among participants with long COVID, including before SARS-CoV-2 infection, suggesting an underlying difference in well-being between groups. Long COVID continued to impact physical functioning, but ongoing changes were not detected by personal well-being scales.
传播所有关于长期新冠对人们生活影响的证据对于为政策和实践提供信息至关重要。我们旨在评估长期新冠患者（定义为症状持续超过1个月）和短期新冠患者（定义为症状在1个月内缓解）在感染新冠病毒前后的五项幸福感指标。
来自澳大利亚维多利亚州的一项纵向队列研究“优化研究”（2020年9月至2022年8月）的参与者，有自我报告的新冠病毒感染史和自我报告的长期新冠状态。系列横断面分析比较了长期和短期新冠患者在个人幸福感指数、经历的新冠样症状数量、锻炼天数以及体验积极和消极情绪的频率方面的情况。
纳入217名参与者，年龄20 - 86岁（中位年龄43岁，四分位间距：31 - 57岁），75%为女性。与短期新冠患者相比，长期新冠患者在感染前（平均差值（MD）=-8.3，95%置信区间（-14.7，-2.0），经调整的p值=0.07）、感染期间（MD=-10.3，95%置信区间（-16.5，-4.0），经调整的p值=0.03）和感染后（MD=-9.91，95%置信区间（-16.71，-3.11），经调整的p值=0.05）的幸福感较低，且在感染期间经历了更多的新冠样症状（MD=1.72（0.72，2.72），经调整的p值=0.03）。在2022年12月，71%（40/56）的人报告在过去4周内执行任务有困难。
总体而言，我们观察到长期新冠患者的幸福感较低，包括在感染新冠病毒之前，这表明两组之间在幸福感方面存在潜在差异。长期新冠继续影响身体功能，但个人幸福感量表未检测到持续变化。
