Largent Emily A, Grill Joshua D, Karlawish Jason, Bleakley Amy
Department of Medical Ethics and Health Policy, University of Pennsylvania, Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104.
Institute for Memory Impairments and Neurological Disorders, University of California Irvine, 3204 Biological Sciences III, Mail Code: 4545, Irvine, CA 92697.
Alzheimers Dement Behav Socioecon Aging. 2025 Sep;1(3). doi: 10.1002/bsa3.70035. Epub 2025 Aug 28.
The steps of participant recruitment are described as a "funnel." In AD secondary prevention trials, the funnel typically yields an unrepresentative study population.
A national survey of U.S. adults aged 65 and over assessed intention to enroll in a hypothetical secondary prevention trial. Among those intending to enroll, intention to ask someone to serve as their study partner was also measured.
In the full sample (n=603), intention to enroll - measured on a scale of 1 (very unlikely) to 5 (very likely) - was low (M: 2.37, SD: 1.31). Among those somewhat or very likely to enroll (24%, n=168), mean intention to ask a study partner was 3.45 out of 5 (SD 1.44). There were no significant differences between Black and White respondents.
Our results suggest underrepresentation of Black older adults in secondary prevention trials is not attributable to lower intention to participate or ask a study partner.
参与者招募的步骤被描述为一个“漏斗”。在阿尔茨海默病二级预防试验中，这个漏斗通常会产生一个缺乏代表性的研究人群。
一项针对65岁及以上美国成年人的全国性调查评估了参与一项假设的二级预防试验的意愿。在那些有意参与的人中，还测量了邀请他人作为其研究伙伴的意愿。
在全样本（n = 603）中，参与意愿（以1分表示极不可能到5分表示极有可能进行衡量）较低（均值：2.37，标准差：1.31）。在那些有点可能或极有可能参与的人（24%，n = 168）中，邀请研究伙伴的平均意愿为5分制中的3.45分（标准差1.44）。黑人和白人受访者之间没有显著差异。
我们的结果表明，老年黑人在二级预防试验中的代表性不足并非归因于参与意愿或邀请研究伙伴的意愿较低。
