2025年6月，英国，Xpert CT/NG检测诊断逃逸突变体的检测与特征分析
Detection and characterisation of Xpert CT/NG assay diagnostic escape mutants, England, June 2025.
作者信息
Jansen van Rensburg Melissa, Pitt-Kendall Rachel, Hincke Michelle, Cliff Penelope R, Shaw Jonathan, Sinka Katy, Saunders John, Fifer Helen, Alexander Sarah
机构信息
Sexually Transmitted Infections Reference Laboratory, UK Health Security Agency, London, United Kingdom.
Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.
出版信息
Euro Surveill. 2025 Sep;30(36). doi: 10.2807/1560-7917.ES.2025.30.36.2500673.
We report the timely detection of a strain of which was confirmed as a diagnostic escape mutant on the Cepheid Xpert CT/NG assay in England in June 2025. The reason for assay failure was a likely recombination event with , which removed both assay target sites. Seven historical putative Xpert CT/NG assay diagnostic escape mutants were also identified following subsequent in silico screening of gonococcal genome collections, but currently there is no evidence of widespread circulation.
我们报告了2025年6月在英格兰及时检测到的一株[细菌名称未给出]，该菌株在赛沛Xpert CT/NG检测中被确认为诊断逃逸突变株。检测失败的原因可能是与[另一细菌名称未给出]发生了重组事件，该事件消除了两个检测靶点。在随后对淋球菌基因组集合进行的计算机模拟筛选中，还鉴定出了7个历史上可能的Xpert CT/NG检测诊断逃逸突变株，但目前尚无广泛传播的证据。
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