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ISG20：癌症研究中的多面“分子明星”（综述）

ISG20: The multifaceted 'molecular star' in cancer research (Review).

作者信息

Zhu Xinhui, Jiang Shihao, Zhang Lipeng, Zou Shaojian, Zhang Houqin, Zhang Jingyu, Chen Liyu, Li Hui, Zong Zhen

机构信息

Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Huan Kui Academy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

出版信息

Oncol Rep. 2025 Nov;54(5). doi: 10.3892/or.2025.8985. Epub 2025 Sep 12.

DOI:10.3892/or.2025.8985
PMID:40937574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12452223/
Abstract

IFN‑stimulated gene (ISG)20 is a key member of the ISG family, serving a central role in antiviral defense, immune regulation and cell metabolism through its exonuclease activity. ISG20 is markedly dysregulated in various malignancies, including clear cell renal cell carcinoma, glioma, breast cancer and hepatocellular carcinoma, and it is associated with tumor proliferation, metastasis, angiogenesis and immune evasion. Its dual regulatory roles, such as promoting tumor progression via the MMP9/CCND1 signaling axis or enhancing antitumor immunity by activating the IFN‑β pathway, highlight its complex involvement in tumor biology. The present review aimed to summarize the discovery, structural characteristics and physiological functions of ISG20, and its multifaceted roles in tumor development. Moreover, the potential of ISG20 as a novel biomarker, immunoadjuvant and therapeutic target is discussed, offering theoretical insight and translational directions for precision oncology.

摘要

干扰素刺激基因（ISG）20是ISG家族的关键成员，通过其核酸外切酶活性在抗病毒防御、免疫调节和细胞代谢中发挥核心作用。ISG20在包括透明细胞肾细胞癌、神经胶质瘤、乳腺癌和肝细胞癌在内的各种恶性肿瘤中明显失调，并且与肿瘤增殖、转移、血管生成和免疫逃逸有关。其双重调节作用，如通过MMP9/CCND1信号轴促进肿瘤进展或通过激活IFN-β途径增强抗肿瘤免疫力，突出了其在肿瘤生物学中的复杂参与。本综述旨在总结ISG20的发现、结构特征和生理功能，及其在肿瘤发生发展中的多方面作用。此外，还讨论了ISG20作为新型生物标志物、免疫佐剂和治疗靶点的潜力，为精准肿瘤学提供理论见解和转化方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/12d19db6526b/or-54-05-08985-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/ec5d9a55f186/or-54-05-08985-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/07fad0406863/or-54-05-08985-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/57c6fe272af3/or-54-05-08985-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/bc67032eaeeb/or-54-05-08985-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/fa3de11ee60f/or-54-05-08985-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/12d19db6526b/or-54-05-08985-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/ec5d9a55f186/or-54-05-08985-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/07fad0406863/or-54-05-08985-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/57c6fe272af3/or-54-05-08985-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/bc67032eaeeb/or-54-05-08985-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/fa3de11ee60f/or-54-05-08985-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7b/12452223/12d19db6526b/or-54-05-08985-g05.jpg

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本文引用的文献

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Genes Immun. 2025 Jun 9. doi: 10.1038/s41435-025-00337-3.
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Multi-omics reveals miR-181a-5p regulates PPAR-driven lipid metabolism in Oral squamous cell carcinoma: Insights from CRISPR/Cas9 knockout models.多组学研究揭示miR-181a-5p调控口腔鳞状细胞癌中PPAR驱动的脂质代谢：来自CRISPR/Cas9基因敲除模型的见解
J Proteomics. 2025 Aug 15;319:105480. doi: 10.1016/j.jprot.2025.105480. Epub 2025 Jun 7.
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Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies.
肿瘤微环境：理解方面的最新进展及其在调节癌症治疗中的作用
Med Oncol. 2025 Mar 18;42(4):117. doi: 10.1007/s12032-025-02641-4.
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FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.FOSL2 介导的 ISG20 转录诱导巨噬细胞 M2 极化，并增强胶质母细胞瘤细胞的致瘤能力。
J Neurooncol. 2024 Sep;169(3):659-670. doi: 10.1007/s11060-024-04771-7. Epub 2024 Jul 29.
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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance.癌症免疫治疗耐药的机制、联合治疗及生物标志物。
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Int Immunopharmacol. 2024 Jun 15;134:112235. doi: 10.1016/j.intimp.2024.112235. Epub 2024 May 17.
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The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.胶质母细胞瘤干细胞中的 PTPRZ1-MET/STAT3/ISG20 轴调节肿瘤相关巨噬细胞极化。
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