Hematological indices derived from complete blood count and unfavorable outcomes in patients under-going peritoneal dialysis.

INTRODUCTION

Understanding the inflammatory processes that are associated with the risk of mortality in patients undergoing peritoneal dialysis (PD) may help guide clinical decision-making and risk and mortality stratification in this population.

OBJECTIVE

To evaluate the association of hematological indices derived from complete blood count with unfavorable outcomes in patients undergoing PD.

METHODS

Prospective cohort with 43 patients undergoing PD follow up for 18 months. Complete blood count data were collected from medical records and the hematological indices were calculated for all participants in the four follow-up waves. Associations between these indices and classic inflammatory markers were investigated by correlation analyses. Patient survival was estimated by the Kaplan Meier method (K-M) after dividing the patients into two groups based on the median as the cut-off point for each hematological index. The Cox model with competitive-risk framework was used to evaluate the influence of indices on survival.

RESULTS

The AISI and SIRI indices had a significant positive correlation with global leukocytes (r = 0.74 and r = 0.71, respectively, p < 0.001). Only AISI and SII showed K-M significant estimates indicating greater survival for AISI ≤149.61 and SII ≤722.80. In the Cox regression model, patients who presented AISI above 149.6 and SII above 722.80 had 9.38 and 4.0 times, respectively, higher risk of death or transfer to HD than other patients.

CONCLUSION

AISI and SII were independently associated with the risk of unfavorable outcomes in PD patients.