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多西环素治疗沙眼衣原体引起的泌尿生殖系统感染的临床评估

[A clinical evaluation of doxycycline in the treatment of genitourinary infections caused by Chlamydia trachomatis].

作者信息

Sumii T, Ohnishi Y, Mita N, Seko S, Nakano H, Nihira H, Tanaka H

出版信息

Jpn J Antibiot. 1985 Nov;38(11):3188-93.

PMID:4094054
Abstract

The clinical effectiveness of doxycycline (DOXY) in the treatment of chlamydial infections was studied by giving it to 14 patients composed of 9 with nongonorrheal urethritis and 5 with cervicitis, all caused by Chlamydia trachomatis. DOXY was given in an oral dose of 100 mg twice daily for 4 to 19 days. The total dosage ranged from 800 to 3,800 mg. The overall clinical efficacy as assessed on the basis of both bacterial response and relief of subjective or objective symptoms was excellent in all of 12 evaluable patients. Two patients for whom we failed to perform postdose bacteriological examinations were excluded from evaluation. No side effect related to dosing of DOXY developed.

摘要

通过对14例由沙眼衣原体引起的衣原体感染患者给药,研究了强力霉素(DOXY)治疗衣原体感染的临床疗效。这14例患者包括9例非淋菌性尿道炎患者和5例宫颈炎患者。强力霉素口服剂量为每日两次,每次100mg,给药4至19天。总剂量范围为800至3800mg。在12例可评估患者中,根据细菌反应以及主观或客观症状缓解情况评估的总体临床疗效极佳。两名未进行给药后细菌学检查的患者被排除在评估之外。未出现与强力霉素给药相关的副作用。

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