衣原体宫颈炎和尿道炎：在社区医疗实践中，单剂量治疗与多西环素治疗七天的比较。
Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises.
作者信息
Thorpe E M, Stamm W E, Hook E W, Gall S A, Jones R B, Henry K, Whitworth G, Johnson R B
机构信息
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38104, USA.
出版信息
Genitourin Med. 1996 Apr;72(2):93-7. doi: 10.1136/sti.72.2.93.
STUDY GOAL
To compare the efficacy and safety of single 1 g oral azithromycin with doxycycline, 100 mg twice daily for seven days for treatment of uncomplicated urogenital chlamydial infection.
STUDY DESIGN
Randomised, unblinded, comparative trial, involving 597 patients demonstrating clinical evidence of genital chlamydia and a positive non-culture assay for Chlamydia trachomatis.
RESULTS
Among the azithromycin- and doxycycline-treated patients 61% and 60%, respectively, were asymptomatic within one week after the first dose. At two weeks, these figures increased to 86% and 83%, respectively. Bacteriological eradication, based on a negative assay, occurred in 338 (97%) of 347 azithromycin-treated patients and 161 (99%) of 163 doxycycline-treated patients.
CONCLUSION
Treatment of uncomplicated chlamydial cervicitis and urethritis with single 1 g oral azithromycin is equivalent to standard therapy with doxycycline. Drug-related adverse events were approximately twice as common as previously reported for both drugs.
研究目标
比较单次口服1克阿奇霉素与每日两次、每次100毫克强力霉素连续服用七天治疗非复杂性泌尿生殖系统衣原体感染的疗效和安全性。
研究设计
随机、非盲、对照试验，纳入597例有生殖器衣原体感染临床证据且沙眼衣原体非培养检测呈阳性的患者。
结果
在接受阿奇霉素和强力霉素治疗的患者中，分别有61%和60%在首剂用药后一周内无症状。两周时，这些数字分别增至86%和83%。基于检测呈阴性的细菌学清除情况，347例接受阿奇霉素治疗的患者中有338例（97%），163例接受强力霉素治疗的患者中有161例（99%）。
结论
单次口服1克阿奇霉素治疗非复杂性衣原体宫颈炎和尿道炎等同于强力霉素标准治疗。与药物相关的不良事件发生率约为这两种药物先前报道的两倍。
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