Niino M, Kida K, Matsuda H, Murase M
Jpn J Antibiot. 1985 Nov;38(11):3334-42.
Efficacy and safety of aztreonam (AZT) for 31 cases of infections of children were studied with the following results. Clinical efficacy of AZT for 22 respiratory tract infections, 5 urinary tract infections and 2 gastrointestinal infections was "excellent" for 19 cases (65.5%), "good" for 9 cases (31.0%) and "poor" for 1 case (3.4%) with an overall effective rate of 96.6%. Microbiological effect of AZT for 19 isolated strains (15 cases) was 100% in disappearance of the Gram-negative bacteria and 89.5% on the whole. With regard to side effect of AZT in 31 cases, there was a slight elevation of GPT in 1 case and eosinophilia in 2 cases. It was considered from the above results that AZT is a useful and safe antibiotic for infections of children.
对31例儿童感染患者使用氨曲南（AZT）进行疗效和安全性研究，结果如下。AZT用于22例呼吸道感染、5例尿路感染和2例胃肠道感染，临床疗效为“优”19例（65.5%），“良”9例（31.0%），“差”1例（3.4%），总有效率为96.6%。AZT对19株分离菌株（15例）的微生物学效果为革兰阴性菌消失率达100%，总体达89.5%。31例患者使用AZT的副作用方面，1例谷丙转氨酶轻度升高，2例嗜酸性粒细胞增多。从上述结果来看，AZT是治疗儿童感染的一种有效且安全的抗生素。
