Kanazawa H, Morita K, Fuwa N
Gan No Rinsho. 1985 Dec;31(15):1858-64.
Twenty-two patients with brain metastases of breast cancer treated by irradiation between 1974 and 1983 were reviewed. Significant neurologic improvement was obtained in 80%. The median duration of symptomatic palliation caused by irradiation and the median survival from the diagnosis of brain metastases were 3.0 months and 5.0 months, respectively. As a favorable prognosis can be expected for patients showing good performance, minor neurologic disorders, a long latent period between the first treatment of the primary lesion and the onset of the brain metastasis, and without extracranial metastases, irradiation with more than 40 Gy is recommended. Sequential CT examinations were useful to judge the effectiveness of treatment.
回顾了1974年至1983年间接受放疗的22例乳腺癌脑转移患者。80%的患者获得了显著的神经功能改善。放疗引起的症状缓解的中位持续时间和脑转移诊断后的中位生存期分别为3.0个月和5.0个月。对于表现良好、轻度神经功能障碍、原发灶首次治疗与脑转移发生之间潜伏期长且无颅外转移的患者，有望获得良好预后，建议放疗剂量超过40 Gy。连续CT检查有助于判断治疗效果。
