Hatoum Firas, Fazili Adnan, Miller Justin W, Wang Xuefeng, Yu Xiaoqing, Lu Xin, S Johnson Jeffrey, Spiess Philippe E, Chahoud Jad
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
USF Health Morsani College of Medicine, Tampa, FL 33602, USA.
Cancers (Basel). 2025 Aug 26;17(17):2774. doi: 10.3390/cancers17172774.
Malignant genitourinary tumors have demonstrated a rising incidence and are characterized by significant morbidity and mortality. Advances in sequencing technologies have greatly enhanced our understanding of the genetic and molecular mechanisms that drive tumor biology. In recent years, spatial transcriptomics technologies have rapidly evolved, enabling precise quantification and visualization of gene expression within the spatial context of tissues. Unlike conventional transcriptomics, which focuses on gene expression levels, spatial transcriptomics provides additional insights into the spatial distribution of genes within tissues, cellular composition, and cell-to-cell interactions within biological samples. In this narrative review, we outline the emerging role and future potential of spatial transcriptomics technology in genitourinary cancers.
恶性泌尿生殖系统肿瘤的发病率呈上升趋势，且具有较高的发病率和死亡率。测序技术的进步极大地增进了我们对驱动肿瘤生物学的遗传和分子机制的理解。近年来，空间转录组学技术迅速发展，能够在组织的空间背景下对基因表达进行精确量化和可视化。与专注于基因表达水平的传统转录组学不同，空间转录组学为组织内基因的空间分布、细胞组成以及生物样本内细胞间相互作用提供了更多见解。在这篇综述中，我们概述了空间转录组学技术在泌尿生殖系统癌症中的新兴作用和未来潜力。
