• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单独灌胃给予苦参碱以及与阿莫西林联合灌胃给予苦参碱后在猪体内的药代动力学

Pharmacokinetics of Matrine in Pigs After Gavage Administration of Matrine Alone and in Combination with Amoxicillin.

作者信息

Li Ruonan, Zhou Danna, Hu Huiyu, Wang Fuhao, Lv Xiaoling, Sun Lei, Sun Xueyan, Yu Daojin, Yang Bo

机构信息

University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

出版信息

Animals (Basel). 2025 Aug 25;15(17):2502. doi: 10.3390/ani15172502.

DOI:10.3390/ani15172502
PMID:40941297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12427342/
Abstract

Bacterial intestinal infections, such as porcine colibacillosis, have caused large economic losses to the global pig industry every year [...].

摘要

细菌性肠道感染，如猪大肠杆菌病，每年给全球养猪业造成巨大经济损失[……]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/e87c8d4e63fa/animals-15-02502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/89eba61d6b93/animals-15-02502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/a716a92817a4/animals-15-02502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/6410d29a8ba0/animals-15-02502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/e87c8d4e63fa/animals-15-02502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/89eba61d6b93/animals-15-02502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/a716a92817a4/animals-15-02502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/6410d29a8ba0/animals-15-02502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5b8/12427342/e87c8d4e63fa/animals-15-02502-g004.jpg

相似文献

1
Pharmacokinetics of Matrine in Pigs After Gavage Administration of Matrine Alone and in Combination with Amoxicillin.单独灌胃给予苦参碱以及与阿莫西林联合灌胃给予苦参碱后在猪体内的药代动力学
Animals (Basel). 2025 Aug 25;15(17):2502. doi: 10.3390/ani15172502.
2
Preventive effect of matrine on clostridium perfringens type A-induced diarrhoea in piglets.苦参碱对A型产气荚膜梭菌诱导的仔猪腹泻的预防作用。
Vet Res Commun. 2025 Aug 26;49(5):289. doi: 10.1007/s11259-025-10856-z.
3
Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications.缺失牙修复干预措施：种植牙植入时使用抗生素预防并发症。
Cochrane Database Syst Rev. 2013 Jul 31;2013(7):CD004152. doi: 10.1002/14651858.CD004152.pub4.
4
Efficient pigs do not always have less environmental impacts: insights from an individual-based model to assess environmental, economic and technical performances.高效的猪并不总是对环境影响更小：基于个体模型评估环境、经济和技术性能的见解。
Animal. 2025 Jul;19(7):101572. doi: 10.1016/j.animal.2025.101572. Epub 2025 Jun 9.
5
Matrine attenuates cerebral ischemia-reperfusion injury via UCP2/AMPKα-mediated suppression of oxidative stress, apoptosis, and neuroinflammation.苦参碱通过UCP2/AMPKα介导的氧化应激、细胞凋亡和神经炎症抑制减轻脑缺血再灌注损伤。
Int Immunopharmacol. 2025 Oct 10;163:115213. doi: 10.1016/j.intimp.2025.115213. Epub 2025 Jul 18.
6
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
7
Effects of wheat-based fermented liquid feed on growth performance, nutrient digestibility, gut microbiota, intestinal morphology, and barrier function in grower-finisher pigs.发酵型小麦液体饲料对生长育肥猪生长性能、养分消化率、肠道微生物区系、肠道形态和屏障功能的影响。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae229.
8
Validation of a phenotyping method to identify porcine reproductive and respiratory syndrome virus-resilient sows and its impact on sow stayability.一种用于识别对猪繁殖与呼吸综合征病毒具有抗性的母猪的表型分析方法的验证及其对母猪留栏率的影响。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae232.
9
Interventions for treating genital Chlamydia trachomatis infection in pregnancy.妊娠期生殖道沙眼衣原体感染的治疗干预措施。
Cochrane Database Syst Rev. 2017 Sep 22;9(9):CD010485. doi: 10.1002/14651858.CD010485.pub2.
10
Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets.苦参碱的安全性评价及其作为饲料添加剂对仔猪生产性能的影响。
Front Vet Sci. 2025 Jul 8;12:1605448. doi: 10.3389/fvets.2025.1605448. eCollection 2025.

本文引用的文献

1
Combining with matrine restores ciprofloxacin efficacy against qnrS producing E. coli in vitro and in vivo.与苦参碱联合使用可在体外和体内恢复环丙沙星对产qnrS大肠杆菌的疗效。
Microb Pathog. 2025 Jan;198:107132. doi: 10.1016/j.micpath.2024.107132. Epub 2024 Nov 19.
2
The Vehicle of Administration and Prandial State May Reduce the Spectrum of Oral Broad-Spectrum Antibiotics (Oxytetracycline, Fosfomycin and Amoxicillin) Administered to Piglets: A Pharmacokinetic/Pharmacodynamic Approach.给药载体和用餐状态可能会缩小给仔猪口服广谱抗生素（土霉素、磷霉素和阿莫西林）的抗菌谱：一种药代动力学/药效学方法。
J Vet Pharmacol Ther. 2025 Jan;48(1):37-43. doi: 10.1111/jvp.13479. Epub 2024 Aug 30.
3
The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli.
苦参碱和盐酸小檗碱协同治疗禽致病性多药耐药大肠杆菌引起的大肠杆菌病。
Poult Sci. 2024 Oct;103(10):104151. doi: 10.1016/j.psj.2024.104151. Epub 2024 Jul 31.
4
Reversal of gentamicin sulfate resistance in avian pathogenic Escherichia coli by matrine combined with berberine hydrochloride.苦参碱联合盐酸小檗碱逆转禽致病性大肠杆菌对硫酸庆大霉素的耐药性。
Arch Microbiol. 2024 Jun 7;206(7):292. doi: 10.1007/s00203-024-04021-4.
5
Matrine reverses the resistance of to cefaclor by inhibiting the mutations in penicillin-binding protein genes ( and ).苦参碱通过抑制青霉素结合蛋白基因（和）中的突变来逆转对头孢克洛的耐药性。
Front Microbiol. 2024 Mar 15;15:1364339. doi: 10.3389/fmicb.2024.1364339. eCollection 2024.
6
Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis.苦参碱通过 GSK-3β/nrf2 介导的线粒体依赖性细胞凋亡诱导肾毒性。
Chem Biol Interact. 2023 Jun 1;378:110492. doi: 10.1016/j.cbi.2023.110492. Epub 2023 Apr 17.
7
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project.LC-MS/MS 法灵敏、快速定量测定小型猪血浆和奶中的阿莫西林：来自 IMI ConcePTION 项目的贡献。
J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107264. doi: 10.1016/j.vascn.2023.107264. Epub 2023 Mar 22.
8
In vitro activity of honey, total alkaloids of Sophora alopecuroides and matrine alone and in combination with antibiotics against multidrug-resistant Pseudomonas aeruginosa isolates.体外研究蜂蜜、苦参总碱和苦参碱单独及与抗生素联合对多重耐药铜绿假单胞菌的活性。
Lett Appl Microbiol. 2022 Jul;75(1):70-80. doi: 10.1111/lam.13705. Epub 2022 Apr 5.
9
Antibacterial activity of honeys and potential synergism of honeys with antibiotics and alkaloid extract of plant against antibiotic-resistant mutant.蜂蜜的抗菌活性以及蜂蜜与抗生素和植物生物碱提取物对耐药突变体的潜在协同作用。
Iran J Basic Med Sci. 2021 May;24(5):623-628. doi: 10.22038/ijbms.2021.54224.12179.
10
Diverse Gene Cassette Arrays Prevail in Commensal From Intensive Farming Swine in Four Provinces of China.不同的基因盒阵列在中国四个省份集约化养殖猪的共生菌中普遍存在。
Front Microbiol. 2020 Oct 14;11:565349. doi: 10.3389/fmicb.2020.565349. eCollection 2020.