Ortiz Freddy, Cárcamo Sofía, Souza-Mello Vanessa, Echeverría Sergio, Sandoval Cristian, Caamaño José
Departamento de Especialidades Médicas, Facultad de Medicina, Universidad de la Frontera, Temuco 4811230, Chile.
Hospital Dr. Hernán Henríquez Aravena, Temuco 4811230, Chile.
Healthcare (Basel). 2025 Sep 1;13(17):2184. doi: 10.3390/healthcare13172184.
The human eye is a remarkable organ that develops from many tissues originating from neuroectodermal, ectodermal, and mesodermal sources. If any of these essential ocular tissues are impaired, it can lead to complete vision loss. Thus, the objective of these case studies is to evaluate the impact of growth factor-rich plasma (PRGF) on the healing process of corneal epithelial injuries. This case series includes three patients with corneal epithelium lesions. The patients were treated with hyaluronic acid and matrix-regenerating agent eye drops for seven days. For a minimum of six more weeks, additional cycles of PRGF eye drops were administered. All three patients demonstrated improvements in visual acuity, reductions in ocular symptoms, and enhanced ocular surface health. In Patient 1, a good postoperative response was obtained after a second surgery. In Patient 2, after 30 days, the corneal leucoma showed a good response and complete recovery. In Patient 3, the ulcer and visual acuity improved 72 h after the treatment began. PRGF eye drops demonstrated efficacy and safety in the treatment of noninfectious corneal ulcers. Additionally, when used in conjunction with other therapies, they have the potential to augment the healing process of corneal ulcers.
人眼是一个非凡的器官，它由许多源自神经外胚层、外胚层和中胚层的组织发育而成。如果这些眼部必需组织中的任何一个受损，都可能导致完全失明。因此，这些病例研究的目的是评估富含生长因子的血浆（PRGF）对角膜上皮损伤愈合过程的影响。该病例系列包括三名角膜上皮病变患者。患者使用透明质酸和基质再生剂眼药水治疗七天。至少再过六周，额外给予PRGF眼药水疗程。所有三名患者的视力均有所改善，眼部症状减轻，眼表健康状况增强。在患者1中，第二次手术后获得了良好 的术后反应。在患者2中，30天后角膜白斑显示出良好反应并完全恢复。在患者3中，治疗开始72小时后溃疡和视力得到改善。PRGF眼药水在治疗非感染性角膜溃疡方面显示出有效性和安全性。此外，当与其他疗法联合使用时，它们有可能增强角膜溃疡的愈合过程。
